ArticleProceedings of the National Academy of Sciences of the United States of America2002
Signature of balancing selection in Arabidopsis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
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119 citing papers in PubMed, 273 citations in OpenAlex.
- Genomic constraint and hypervariability correlate with fitness effects in elite tetraploid potato breeding material.PLoS genetics · 2026Article
- What has population genomics told us about the dynamics of selection and plant adaptation?Molecular biology and evolution · 2026Review
- Interchromosomal linkage disequilibrium analysis reveals strong indications of sign epistasis in wheat breeding families.G3 (Bethesda, Md.) · 2026Article
- Patterns of presence-absence variation of NLRs across populations of Solanum chilense are clade-dependent and mainly shaped by past demographic history.The New phytologist · 2025Article
- Absence of long-term balancing selection on variation in EuMYB3, an R2R3-MYB gene responsible for the anther-color polymorphism in Erythronium umbilicatum.Scientific reports · 2024Article
- Profile of Joy M. Bergelson.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genome-Wide Associations with Resistance to Bipolaris Leaf Spot (Plants (Basel, Switzerland) · 2022Article
- Global Genetic Heterogeneity in Adaptive Traits.Molecular biology and evolution · 2021Article
- Phylogenetic analysis of ABCG subfamily proteins in plants: functional clustering and coevolution with ABCGs of pathogens.Physiologia plantarum · 2021Article
- Plant NLR diversity: the known unknowns of pan-NLRomes.The Plant cell · 2021Review
- A New Catalog of Structural Variants in 1,301 A. thaliana Lines from Africa, Eurasia, and North America Reveals a Signature of Balancing Selection at Defense Response Genes.Molecular biology and evolution · 2021Article
- Using High-Density SNP Array to Reveal Selection Signatures Related to Prolificacy in Chinese and Kazakhstan Sheep Breeds.Animals : an open access journal from MDPI · 2020Article
- Allele mining unlocks the identification of RYMV resistance genes and alleles in African cultivated rice.BMC plant biology · 2020Article
- Herbivore-mediated negative frequency-dependent selection underlies a trichome dimorphism in nature.Evolution letters · 2020Article
- Evolutionary dynamics and impacts of chromosome regions carrying R-gene clusters in rice.Scientific reports · 2020Article
- High Resolution Mapping of aFrontiers in plant science · 2020Article
- Immunodiversity of theFrontiers in plant science · 2020Article
- Hybrid Incompatibility of the Plant Immune System: An Opposite Force to Heterosis Equilibrating Hybrid Performances.Frontiers in plant science · 2020Review
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59 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Natural selection and genetic linkage cause DNA segments to have genealogical histories resembling those of the selected sites. When a polymorphism maintained by selection is old, it will have an island of enhanced sequence variability surrounding it, which represents a detectable "signature of selection." We investigate the structure of single-nucleotide polymorphisms (SNPs) in a 20-kb interval containing the Arabidopsis thaliana disease resistance gene RPS5, a locus containing common alleles for the presence/absence of the entire locus. The alleles are considerably diverged at surrounding sites, indicative of an old polymorphism maintained by selection. The island of "enhanced" variability extends several kilobases to either side of the RPS5 deletion junction, and these SNPs are in nearly complete linkage disequilibrium with the RPS5 insertion/deletion. At a distance of 10 kb to either side of the locus, however, we find low levels of polymorphism and the absence of linkage disequilibrium between individual SNPs and RPS5 alleles. Our results show that the interval of enhanced variability surrounding this balanced polymorphism in Arabidopsis is large enough to be readily detected, but small enough to span the focal gene and few others. For this species it should be possible to identify the complete set of genes with long-lived polymorphisms, a potentially important subset of genes segregating for functional variants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.