ArticleProceedings of the National Academy of Sciences of the United States of America2002
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- MonoallelicFrontiers in immunology · 2022Article
- Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.Haematologica · 2017Article
- E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease.Developmental cell · 2015Review
- Transcription factors and target genes of pre-TCR signaling.Cellular and molecular life sciences : CMLS · 2015Review
- Placing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts.BioMed research international · 2015Review
- Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The ID proteins: master regulators of cancer stem cells and tumour aggressiveness.Nature reviews. Cancer · 2014Review
- E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.Blood · 2013Article
- T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate.Nature immunology · 2010Article
- Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.Genes & development · 2010Article
- A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis.Cancer research · 2009Article
- Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1.The Journal of experimental medicine · 2008Article
- Article
- Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling.Blood · 2006Article
- Article
- E2A proteins enforce a proliferation checkpoint in developing thymocytes.The EMBO journal · 2004Article
- Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma.EMBO reports · 2003Article
- Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents.Oncogene · 2003Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The helix-loop-helix proteins E47 and E12, which are encoded by the E2A gene, regulate several stages of T cell development. In addition, mice deficient for E2A are highly susceptible to thymic lymphoma. Here we report that the development of lymphoma in E2A-deficient mice did not require pre- and recombinase-activating gene expression. Rather, we found that, whereas illegitimate DNA rearrangement did not play a major role in the development of these lymphomas, defects that prevented pre-T cell antigen receptor expression tended to accelerate lymphomagenesis in E2A-deficient mice. These data and previous observations also provide insight into the role of Notch in lymphoma development. Specifically, we propose that Notch activation indirectly modulates E2A activity through induction of pre-Talpha expression, ultimately leading to the development of lymphoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.