ArticleJournal of bioenergetics and biomembranes2002
Does any yeast mitochondrial carrier have a native uncoupling protein function?
Article in Journal of bioenergetics and biomembranes, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation.Antioxidants (Basel, Switzerland) · 2024Review
- Fresh Insights IntoOncology reviews · 2024Review
- Mitochondrial electron transport chain, ROS generation and uncoupling (Review).International journal of molecular medicine · 2019Article
- The neuroprotective steroid progesterone promotes mitochondrial uncoupling, reduces cytosolic calcium and augments stress resistance in yeast cells.Microbial cell (Graz, Austria) · 2017Article
- Physiological and pathological roles of mitochondrial SLC25 carriers.The Biochemical journal · 2013Review
- The evolutionary trajectory of mitochondrial carrier family during metazoan evolution.BMC evolutionary biology · 2010Article
- Mitochondrial proton and electron leaks.Essays in biochemistry · 2010Review
- Metal acquisition and availability in the mitochondria.Chemical reviews · 2009Review
- Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria.Journal of bioenergetics and biomembranes · 2009Article
- Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.Neuromolecular medicine · 2006Article
- The basal proton conductance of mitochondria depends on adenine nucleotide translocase content.The Biochemical journal · 2005Article
- Identification and functional reconstitution of yeast mitochondrial carrier for S-adenosylmethionine.The EMBO journal · 2003Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we explore the hypothesis that some member of the mitochondrial carrier family has specific uncoupling activity that is responsible for the basal proton conductance of mitochondria. Twenty-seven of the 35 yeast mitochondrial carrier genes were independently disrupted in Saccharomyces cerevisiae. Six knockout strains did not grow on nonfermentable carbon sources such as lactate. Mitochondria were isolated from the remaining 21 strains, and their proton conductances were measured. None of the 21 carriers contributed significantly to the basal proton leak of yeast mitochondria. A possible exception was the succinate/fumarate carrier encoded by the Xc2 gene, but deletion of this gene also affected yeast growth and respiratory chain activity, suggesting a more general alteration in mitochondrial function. If a specific protein is responsible for the basal proton conductance of yeast mitochondria, its identity remains unknown.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.