ArticleAnnals of surgery2002
Propranolol decreases splanchnic triacylglycerol storage in burn patients receiving a high-carbohydrate diet.
Article in Annals of surgery, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Metabolic implications of severe burn injuries and their management: a systematic review of the literature.World journal of surgery · 2008Pooled it
- Reversal of Growth Arrest With the Combined Administration of Oxandrolone and Propranolol in Severely Burned Children.Annals of surgery · 2016Trial
- Glucose Control in Severely Burned Patients Using Metformin: An Interim Safety and Efficacy Analysis of a Phase II Randomized Controlled Trial.Annals of surgery · 2016Trial
- Pathophysiologic response to severe burn injury.Annals of surgery · 2008Trial
- Metabolic response to burn injury: a comprehensive bibliometric study.Frontiers in medicine · 2024Article
- Application of beta-blockers in burn management.Proceedings (Baylor University. Medical Center) · 2022Article
- The impact of catecholamines on skeletal muscle following massive burns: Friend or foe?Burns : journal of the International Society for Burn Injuries · 2021Review
- Current problems in burn hypermetabolism.Current problems in surgery · 2020Review
- Children with severe burns display no sex differences in exercise capacity at hospital discharge or adaptation after exercise rehabilitation training.Burns : journal of the International Society for Burn Injuries · 2018Article
- Burn injury: review of pathophysiology and therapeutic modalities in major burns.Annals of burns and fire disasters · 2017Article
- Burns in children: standard and new treatments.Lancet (London, England) · 2014Review
- Is propranolol of benefit in pediatric burn patients?Advances in surgery · 2013Review
- Association of postburn fatty acids and triglycerides with clinical outcome in severely burned children.The Journal of clinical endocrinology and metabolism · 2013Article
- Role of β-adrenergic receptors in regulation of hepatic fat accumulation during aging.The Journal of endocrinology · 2012Article
- The hypermetabolic response to burn injury and interventions to modify this response.Clinics in plastic surgery · 2009Review
- Modulation of the hypermetabolic response to trauma: temperature, nutrition, and drugs.Journal of the American College of Surgeons · 2009Article
- Nutritional and Pharmacological Modulation of the Metabolic Response of Severely Burned Patients: Review of the Literature (Part II)*.Annals of burns and fire disasters · 2008Article
- The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly.Annals of surgery · 2006Article
- The hepatic response to thermal injury: is the liver important for postburn outcomes?Molecular medicine (Cambridge, Mass.)Review
- Alcohol Modulation of the Postburn Hepatic Response.Journal of burn care & research : official publication of the American Burn AssociationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo quantify the various components of splanchnic free fatty acid and very-low-density lipoprotein-triacylglycerol (VLDL-TAG) metabolism in order to gain insight into the mechanisms responsible for the development of fatty liver in severely burned patients, and to determine if decreasing free fatty acid availability by use of propranolol could potentially reduce hepatic fatty acid accumulation. SUMMARY BACKGROUND DATA: Hepatic fat accumulation results from an imbalance between fatty acid uptake, oxidation, and release via VLDL-TAG. Fatty acid delivery is accelerated in burn patients because of stimulated lipolysis. Since propranolol decreases lipolysis, it should also decrease hepatic fatty acid uptake and thus TAG synthesis.
methodsStable isotope-labeled tracers and regional catheterization enabled quantification of various parameters of lipid metabolism across the splanchnic bed in severely burned patients. The acute effects of propranolol treatment were studied in all patients, and in a subgroup of patients the chronic (3 weeks) effects of propranolol were assessed.
resultsThe rate of splanchnic uptake of palmitate was 1.68 +/- 1.3 micromol/kg/min, whereas the rates of oxidation and VLDL-TG secretion were only 0.12 +/- 0.11 and 0.003 +/- 0.02 micromol/kg/min, respectively. Propranolol significantly reduced palmitate delivery, and thus palmitate uptake, without significantly affecting oxidation or VLDL-TAG secretion. Thus, palmitate storage was reduced from 1.53 +/- 1.30 micromol/kg/min without propranolol to 0.76 +/- 0.58 micromol/kg/min after propranolol.
conclusionsHepatic fat storage in burn patients is due to low rates of both fatty acid oxidation and VLDL-TAG secretion. Propranolol can decrease hepatic fat storage by limiting fatty acid delivery.
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Registered trials
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