ArticleThe EMBO journal2002
The C.elegans MAPK phosphatase LIP-1 is required for the G(2)/M meiotic arrest of developing oocytes.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 62 citations in OpenAlex.
- Conserved Gαq-PLCβ-PKC signaling mediates trametinib resistance in BRAFbioRxiv : the preprint server for biology · 2025Article
- Lessons on the force-form-function connection in cell biology from modeling a syncytial germline.Current opinion in cell biology · 2025Review
- A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling.Nature cell biology · 2025Article
- Genetic and Chemical Controls of Sperm Fate and Spermatocyte Dedifferentiation via PUF-8 and MPK-1 inCells · 2023Article
- Reevaluation of the role of LIP-1 as an ERK/MPK-1 dual specificity phosphatase in theProceedings of the National Academy of Sciences of the United States of America · 2022Article
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- Phospho-Regulation of Meiotic Prophase.Frontiers in cell and developmental biology · 2021Review
- MiR-35 buffers apoptosis thresholds in the C. elegans germline by antagonizing both MAPK and core apoptosis pathways.Cell death and differentiation · 2019Article
- Progression of Meiosis Is Coordinated by the Level and Location of MAPK Activation Via OGR-2 inGenetics · 2019Article
- Spatiotemporal Gene Expression Analysis of theGenetics · 2018Article
- Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline.The FEBS journal · 2018Article
- MPK-1/ERK regulatory network controls the number of sperm by regulating timing of sperm-oocyte switch in C. elegans germline.Biochemical and biophysical research communications · 2017Article
- A Phenotype-Based RNAi Screening for Ras-ERK/MAPK Signaling-Associated Stem Cell Regulators in C. elegans.Methods in molecular biology (Clifton, N.J.) · 2017Article
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- Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegans.Genes & development · 2016Article
- A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification.BMB reports · 2016Review
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- Emergent stem cell homeostasis in the C. elegans germline is revealed by hybrid modeling.Biophysical journal · 2015Article
- Functional specialization of chordate CDK1 paralogs during oogenic meiosis.Cell cycle (Georgetown, Tex.) · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the Caenorhabditis elegans hermaphrodite germline, spatially restricted mitogen-activated protein kinase (MAPK) signalling controls the meiotic cell cycle. First, the MAPK signal is necessary for the germ cells to progress through pachytene of meiotic prophase I. As the germ cells exit pachytene and enter diplotene/diakinesis, MAPK is inactivated and the developing oocytes arrest in diakinesis (G(2)/M arrest). During oocyte maturation, a signal from the sperm reactivates MAPK to promote M phase entry. Here, we show that the MAPK phosphatase LIP-1 dephosphorylates MAPK as germ cells exit pachytene in order to maintain MAPK in an inactive state during oocyte development. Germ cells lacking LIP-1 fail to arrest the cell cycle at the G(2)/M boundary, and they enter a mitotic cell cycle without fertilization. LIP-1 thus coordinates oocyte cell cycle progression and maturation with ovulation and fertilization.
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