ArticleThe EMBO journal2002
Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Reduction of endocytosis and EGFR signaling is associated with the switch from isolated to clustered apoptosis during epithelial tissue remodeling in Drosophila.PLoS biology · 2024Article
- Buffered EGFR signaling regulated by spitz-to-argos expression ratio is a critical factor for patterning the Drosophila eye.PLoS genetics · 2023Article
- Activation of EGFR signaling by Tc-Vein and Tc-Spitz regulates the metamorphic transition in the red flour beetle Tribolium castaneum.Scientific reports · 2021Article
- EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development.PLoS biology · 2018Article
- Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer.Cancers · 2017Review
- ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling.Journal of cell science · 2016Article
- Regulatory mechanisms of EGFR signalling during Drosophila eye development.Cellular and molecular life sciences : CMLS · 2016Review
- Maintenance of glia in the optic lamina is mediated by EGFR signaling by photoreceptors in adult Drosophila.PLoS genetics · 2015Article
- Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues.Journal of cell science · 2013Article
- EGFR signaling modulates synaptic connectivity via Gurken.Developmental neurobiology · 2012Article
- EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila.Cell stem cell · 2011Article
- EGF signaling and the origin of axial polarity among the insects.Current biology : CB · 2010Article
- Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila.PLoS genetics · 2010Article
- The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development.PloS one · 2010Article
- EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors.Development (Cambridge, England) · 2009Article
- Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases.The EMBO journal · 2008Article
- Rhomboid cleaves Star to regulate the levels of secreted Spitz.The EMBO journal · 2007Article
- Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis.BMC evolutionary biology · 2006Article
- A Drosophila model of multiple endocrine neoplasia type 2.Genetics · 2005Article
- Regulation of the Drosophila epidermal growth factor-ligand vein is mediated by multiple domains.Genetics · 2004Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Spitz (Spi) is the most prominent ligand of the Drosophila EGF receptor (DER). It is produced as an inactive membrane precursor which is retained in the endoplasmic reticulum (ER). To allow cleavage, Star transports Spi to the Golgi, where it undergoes cleavage by Rhomboid (Rho). Since some DER phenotypes are not mimicked by any of its known activating ligands, we identified an additional ligand by database searches, and termed it Keren (Krn). Krn is a functional homolog of Spi since it can rescue the spi mutant phenotype in a Rho- and Star-dependent manner. In contrast to Spi, however, Krn also possesses a Rho/Star-independent ability to undergo low-level cleavage and activate DER, as evident both in cell culture and in flies. The difference in basal activity correlates with the cellular localization of the two ligands. While Spi is retained in the ER, the retention of Krn is only partial. Examining Spi/Krn chimeric and deletion constructs implicates the Spi cytoplasmic domain in inhibiting its basal activity. Low-level activity of Krn calls for tightly regulated expression of the Krn precursor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.