ArticleMolecular and cellular biology2002
Identification of novel MyoD gene targets in proliferating myogenic stem cells.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 51 citations in OpenAlex.
- In vivo self-renewal and expansion of quiescent stem cells from a non-human primate.Nature communications · 2025Article
- A Developmental Gene Expression Atlas Reveals Novel Biological Basis of Complex Phenotypes in Sheep.Genomics, proteomics & bioinformatics · 2025Article
- The Comparison of Commercial Serum-Free Media for Hanwoo Satellite Cell Proliferation and the Role of Fibroblast Growth Factor 2.Food science of animal resources · 2023Article
- Article
- Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells.International journal of molecular sciences · 2022Article
- Myogenin is required for assembly of the transcription machinery on muscle genes during skeletal muscle differentiation.PloS one · 2021Article
- Atmospheric Ammonia Affects Myofiber Development and Lipid Metabolism in Growing Pig Muscle.Animals : an open access journal from MDPI · 2019Article
- Salidroside mitigates skeletal muscle atrophy in rats with cigarette smoke-induced COPD by up-regulating myogenin and down-regulating myostatin expression.Bioscience reports · 2019Article
- Ascl2 inhibits myogenesis by antagonizing the transcriptional activity of myogenic regulatory factors.Development (Cambridge, England) · 2017Article
- MyoD directly up-regulates premyogenic mesoderm factors during induction of skeletal myogenesis in stem cells.The Journal of biological chemistry · 2011Article
- Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loading.Physiological genomics · 2010Article
- CORE_TF: a user-friendly interface to identify evolutionary conserved transcription factor binding sites in sets of co-regulated genes.BMC bioinformatics · 2008Article
- Defining the transcriptional signature of skeletal muscle stem cells.Journal of animal science · 2008Review
- Microarray analysis of the temporal response of skeletal muscle to methylprednisolone: comparative analysis of two dosing regimens.Physiological genomics · 2007Article
- MyoD induces myogenic differentiation through cooperation of its NH2- and COOH-terminal regions.The Journal of cell biology · 2005Article
- Mutant MyoD lacking Cdc2 phosphorylation sites delays M-phase entry.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A major control point for skeletal myogenesis revolves around the muscle basic helix-loop-helix gene family that includes MyoD, Myf-5, myogenin, and MRF4. Myogenin and MRF4 are thought to be essential to terminal differentiation events, whereas MyoD and Myf-5 are critical to establishing the myogenic cell lineage and producing committed, undifferentiated myogenic stem cells (myoblasts). Although mouse genetic studies have revealed the importance of MyoD and Myf-5 for myoblast development, the genetic targets of MyoD and Myf-5 activity in undifferentiated myoblasts remain unknown. In this study, we investigated the function of MyoD as a transcriptional activator in undifferentiated myoblasts. By using conditional expression of MyoD, in conjunction with suppression subtractive hybridizations, we show that the Id3 and NP1 (neuronal pentraxin 1) genes become transcriptionally active following MyoD induction in undifferentiated myoblasts. Activation of Id3 and NP1 represents a stable, heritable event that does not rely on continued MyoD activity and is not subject to negative regulation by an activated H-Ras G12V protein. These results are the first to demonstrate that MyoD functions as a transcriptional activator in myogenic stem cells and that this key myogenic regulatory factor exhibits different gene target specificities, depending upon the cellular environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.