ArticleProceedings of the National Academy of Sciences of the United States of America2002
Glutamatergic activity in the amygdala signals visceral input during taste memory formation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 96 citations in OpenAlex.
- Amygdala reactivity to social stress in young adults: A scoping review of neuroimaging studies.Neurobiology of stress · 2026Review
- Gene losses, parallel evolution and heightened expression confer adaptations to dedicated cleaning behaviour.BMC biology · 2023Article
- Selective TAAR1 agonists induce conditioned taste aversion.Psychopharmacology · 2022Article
- Maintenance of conditioned place avoidance induced by gastric malaise requires NMDA activity within the ventral hippocampus.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Taste association capabilities differ in high- and low-yawning rats versus outbred Sprague-Dawley rats after prolonged sugar consumption.Animal cognition · 2021Article
- Review
- Glutamatergic basolateral amygdala to anterior insular cortex circuitry maintains rewarding contextual memory.Communications biology · 2020Article
- The hypothalamus to brainstem circuit suppresses late-onset body weight gain.Scientific reports · 2019Article
- The Functional and Neurobiological Properties of Bad Taste.Physiological reviews · 2019Review
- The possible mechanisms of analgesia produced by microinjection of morphine into the lateral habenula in the acute model of trigeminal pain in rats.Research in pharmaceutical sciences · 2017Article
- Memory trace reactivation and behavioral response during retrieval are differentially modulated by amygdalar glutamate receptors activity: interaction between amygdala and insular cortex.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Estradiol enhances the acquisition of lithium chloride-induced conditioned taste aversion in castrated male rats.Die Naturwissenschaften · 2015Article
- Glutamate Receptors in the Central Nucleus of the Amygdala Mediate Cisplatin-Induced Malaise and Energy Balance Dysregulation through Direct Hindbrain Projections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Stress as a one-armed bandit: Differential effects of stress paradigms on the morphology, neurochemistry and behavior in the rodent amygdala.Neurobiology of stress · 2015Review
- Article
- Blockade of stimulus convergence in amygdala neurons disrupts taste associative learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Repeated cycles of chronic intermittent ethanol exposure leads to the development of tolerance to aversive effects of ethanol in C57BL/6J mice.Alcoholism, clinical and experimental research · 2012Article
- Mitogen-activated protein kinase in the amygdala plays a critical role in lithium chloride-induced taste aversion learning.Neurobiology of learning and memory · 2012Article
- Electrical activity in rat cortico-limbic structures after single or repeated administration of lipopolysaccharide or staphylococcal enterotoxin B.Proceedings. Biological sciences · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conditioned taste aversion (CTA) is a learning paradigm in which an animal avoids a taste (conditioned stimulus) previously associated with visceral toxic effects [or unconditioned stimulus (US)]. Although many studies have implicated glutamate-mediated neurotransmission in memory consolidation of different types of learning tasks, including CTA, the exact role of this neurotransmitter system in memory formation is not known. Thus, we set out to determine whether glutamate mediates signaling of the US in CTA. We present evidence obtained by in vivo microdialysis that the US (i.p. injection of lithium chloride) induced a dramatic increase in glutamate release in the amygdala and a modest but significant release in the insular cortex. Moreover, CTA can be elicited by intra-amygdalar microinjections of glutamate; consequently, when glutamate is administered just before the presentation of a weak US, a clear CTA is induced. In contrast, the injection of glutamate alone or glutamate 2 h after the suboptimal US did not have any effect on the acquisition of CTA. These results indicate that glutamate activation of the amygdala can partially substitute the US in CTA, thus providing a clear indication that the amygdala conveys visceral information for this kind of memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.