ArticleThe Journal of cell biology2002
Nuclear DNA helicase II is recruited to IFN-alpha-activated transcription sites at PML nuclear bodies.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus.eLife · 2023Article
- Nucleic DHX9 cooperates with STAT1 to transcribe interferon-stimulated genes.Science advances · 2023Article
- Review
- H(+)/Cl(‑) exchange transporter 7 promotes lysosomal acidification‑mediated autophagy in mouse cardiomyocytes.Molecular medicine reports · 2021Article
- A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway.Theranostics · 2021Article
- PML nuclear bodies and chromatin dynamics: catch me if you can!Nucleic acids research · 2020Review
- Interleukin-37 inhibits osteoclastogenesis and alleviates inflammatory bone destruction.Journal of cellular physiology · 2019Article
- Cellular RNA Helicase DHX9 Interacts with the Essential Epstein-Barr Virus (EBV) Protein SM and Restricts EBV Lytic Replication.Journal of virology · 2019Article
- The Host DHX9 DExH-Box Helicase Is Recruited to Chikungunya Virus Replication Complexes for Optimal Genomic RNA Translation.Journal of virology · 2019Article
- The biology of DHX9 and its potential as a therapeutic target.Oncotarget · 2016Review
- Nuclear actin and myosins in adenovirus infection.Experimental cell research · 2015Article
- Review
- DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication.Biochimica et biophysica acta · 2013Review
- PML promotes MHC class II gene expression by stabilizing the class II transactivator.The Journal of cell biology · 2012Article
- PML nuclear bodies.Cold Spring Harbor perspectives in biology · 2010Review
- Identification of RNA helicase A as a new host factor in the replication cycle of foot-and-mouth disease virus.Journal of virology · 2009Article
- An antiviral response directed by PKR phosphorylation of the RNA helicase A.PLoS pathogens · 2009Article
- Nuclear factors are involved in hepatitis C virus RNA replication.RNA (New York, N.Y.) · 2007Article
- Advances in imaging the interphase nucleus using thin cryosections.Histochemistry and cell biology · 2007Review
- Quantitative analysis of cell nucleus organisation.PLoS computational biology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is known that nuclear DNA helicase II (NDH II) links CREB-binding protein directly to RNA polymerase II holoenzyme, and that this interaction is essential for gene activation by CREB. Here, we report for the first time that some NDH II/RNA helicase A is a component of promyelocytic leukemia nuclear bodies (PML NBs). An autoimmune serum specific for PML NBs was identified and used in immunoprecipitation experiments. NDH II was present in the immunoprecipitates as shown by mass spectrometry and by immunoblotting. Immunofluorescence and ultrastructural studies showed that NDH II colocalizes with a small subset of PML NBs in control cells, however, colocalizes with practically all bodies in interferon-alpha-stimulated cells. After interferon stimulation, more PML NBs were found to contain newly synthesized RNA, as indicated by bromouridine incorporation. PML NBs also contain RNA polymerase II. The association of NDH II with PML NBs was transcriptionally dependent, and NDH II was present in all bodies with nascent RNA. Blocking of mRNA synthesis caused NDH II relocalization from nucleoplasm to nucleoli. Based on the data, we suggest that NDH II recruitment to PML NBs is connected with transcriptional regulation of interferon-alpha-inducible genes attached to PML NBs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.