ArticleThe American journal of pathology2002
Molecular characterization of human meningiomas by gene expression profiling using high-density oligonucleotide microarrays.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression.Proceedings of the National Academy of Sciences of the United States of America · 2004Pooled it
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- Sonic hedgehog signalling pathway in CNS tumours: its role and therapeutic implications.Molecular brain · 2024Review
- Evaluation of prognostic biomarkers in meningiomas and their clinical implications in settings with limited resources.Neuro-oncology practice · 2024Article
- Single-cell transcriptome analysis upon ECM-remodeling meningioma cells.Neurosurgical review · 2024Article
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- The expression and prognostic value of the epidermal growth factor receptor family in glioma.BMC cancer · 2021Article
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- Overexpressed gene signature of EPH receptor A/B family in cancer patients-comprehensive analyses from the public high-throughput database.International journal of clinical and experimental pathology · 2020Article
- Expression and prognostic value of brain and acute leukemia, cytoplasmic in meningiomas.Chinese medical journal · 2019Article
- An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.Scientific reports · 2018Article
- Predictors of early progression of surgically treated atypical meningiomas.Acta neurochirurgica · 2018Article
- Validation of Reference Genes for Expression Studies in Human Meningiomas under Different Experimental Settings.Molecular neurobiology · 2018Article
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- A description of familial clustering of meningiomas in the Utah population.Neuro-oncology · 2017Article
- Simultaneous analysis of miRNA-mRNA in human meningiomas by integrating transcriptome: A relationship between PTX3 and miR-29c.BMC cancer · 2017Article
- Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling.Cancers · 2016Review
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- Histone deacetylase inhibitor AR-42 differentially affects cell-cycle transit in meningeal and meningioma cells, potently inhibiting NF2-deficient meningioma growth.Cancer research · 2013Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Meningiomas are common central nervous system neoplasms that exhibit remarkably diverse histopathology and biological behavior. Compared to astrocytomas, the most common central nervous system tumor, little is known about the molecular pathways critical for meningioma tumor formation and malignant progression. As an initial step toward characterizing the genetic basis of meningioma pathogenesis, we assessed cancer-related gene expression profiles of nonneoplastic leptomeningeal specimens and human meningiomas of varying World Health Organization (WHO) grade using high-density oligonucleotide microarrays. Although expression profile differences between nonneoplastic and meningioma specimens were readily discernible, the expression profile of a subset of genes could also distinguish WHO grade I from WHO grades II and III tumors. Altered expression levels of several genes identified in this study have been previously noted in meningiomas (eg, growth hormone receptor, IGFBP-7, endothelin receptor A, IGF2). However, we also identified a number of novel genes whose expression was associated with WHO grade and was confirmed by reverse transcriptase-polymerase chain reaction in a larger, independent set of meningeal tumors (n = 47). This report represents the first gene expression profiling studies of meningiomas and identifies some initial candidate genes that may provide further insights into the genetic basis for meningioma pathogenesis.
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