ArticleThe American journal of pathology2002
Guanylin and functional coupling proteins in the human salivary glands and gland tumors : expression, cellular localization, and target membrane domains.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- The Role of Uroguanylin in Regulation of Ion Transport in Salivary Glands.Acta stomatologica Croatica · 2023Article
- Inhibition of Alk signaling promotes the induction of human salivary-gland-derived organoids.Disease models & mechanisms · 2020Article
- Salivary Biomarkers and Oral Microbial Load in Relation to the Dental Status of Adults with Cystic Fibrosis.Microorganisms · 2019Article
- Localization of cystic fibrosis transmembrane conductance regulator signaling complexes in human salivary gland striated duct cells.European journal of oral sciences · 2015Article
- From Escherichia coli heat-stable enterotoxin to mammalian endogenous guanylin hormones.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Review
- Guanylin and functional coupling proteins in the hepatobiliary system of rat and guinea pig.Histochemistry and cell biology · 2012Article
- The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila.PloS one · 2012Article
- GUCY2C-targeted cancer immunotherapy: past, present and future.Immunologic research · 2011Review
- Regulation of dental enamel shape and hardness.Journal of dental research · 2010Review
- Can colorectal cancer be prevented or treated by oral hormone replacement therapy?Current molecular pharmacology · 2009Review
- Localization of the iron-regulatory proteins hemojuvelin and transferrin receptor 2 to the basolateral membrane domain of hepatocytes.Histochemistry and cell biology · 2007Article
- Guanylin-immunoreactive cells in the female and male rat adenohypophysis and their changes under various physiological and experimental conditions.Histochemistry and cell biology · 2005Article
- Article
- Salivary gland neoplasms.Current treatment options in oncology · 2004Review
- GCC signaling in colorectal cancer: Is colorectal cancer a paracrine deficiency syndrome?Drug news & perspectivesReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated secretion of an electrolyte-rich fluid is a major but incompletely understood function of the salivary glands. We provide molecular evidence that guanylin, a bioactive intestinal peptide involved in the CFTR-regulated secretion of electrolyte/water in the gut epithelium, is highly expressed in the human parotid and submandibular glands and in respective clinically most relevant tumors. Moreover, in the same organs we identified expression of the major components of the guanylin signaling pathway, ie, guanylin-receptor guanylate cyclase-C, cGKII, and CFTR, as well as of the epithelial Cl(-)/HCO(3)(-) anion exchanger type 2 (AE2). At the cellular level, guanylin is localized to epithelial cells of the ductal system that, based on its presence in the saliva, is obviously released into the salivary gland ducts. The guanylin-receptor guanylate cyclase-C, cGKII, CFTR, and AE2 are all confined exclusively to the apical membrane of the same duct cells. These findings implicate guanylin as intrinsic regulator of electrolyte secretion in the salivary glands. We assume that duct epithelial cells synthesize and release guanylin into the saliva to regulate electrolyte secretion in the ductal system by an intraductal luminocrine signaling pathway. Moreover, the high expression of guanylin in pleomorphic adenoma and Warthin tumors (cystadenolymphoma), the most common neoplasms of salivary glands, predicts guanylin as a significant marker in tumor pathology.
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