ArticleThe American journal of pathology2002
Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- Characterization of the human immune cell network at the gingival barrier.Mucosal immunology · 2016Trial
- Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation.Cell reports · 2026Article
- Review
- Blockade of Platelet CysLT1R Receptor with Zafirlukast Counteracts Platelet Protumoral Action and Prevents Breast Cancer Metastasis to Bone and Lung.International journal of molecular sciences · 2022Article
- Review
- Article
- Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism.Biomolecules · 2019Article
- High-affinity pan-specific monoclonal antibodies that target cysteinyl leukotrienes and show efficacy in an acute model of colitis.Journal of lipid research · 2017Article
- Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4.Journal of lipid research · 2016Article
- Sputum RNA signature in allergic asthmatics following allergen bronchoprovocation test.European clinical respiratory journal · 2016Article
- Leukotriene enhanced allergic lung inflammation through induction of chemokine production.Clinical and experimental medicine · 2015Article
- Immunolabeling of gamma-glutamyl transferase 5 in normal human tissues reveals that expression and localization differ from gamma-glutamyl transferase 1.Histochemistry and cell biology · 2015Article
- Article
- Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Unveiling the roles of the glutathione redox system in vivo by analyzing genetically modified mice.Journal of clinical biochemistry and nutrition · 2011Article
- Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes.Analytical biochemistry · 2011Article
- Redox regulation of gamma-glutamyl transpeptidase.American journal of respiratory cell and molecular biology · 2009Review
- Lung lining fluid glutathione attenuates IL-13-induced asthma.American journal of respiratory cell and molecular biology · 2008Article
- The human gamma-glutamyltransferase gene family.Human genetics · 2008Article
- Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells.American journal of respiratory cell and molecular biology · 2006Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The metabolism of cysteinyl leukotrienes in vivo and the pathophysiological effects of individual cysteinyl leukotrienes are primarily unknown. Recently we identified an additional member of the gamma-glutamyl transpeptidase (GGT) family, gamma-glutamyl leukotrienase (GGL), and developed mice deficient in this enzyme. Here we show that in vivo GGL, and not GGT as previously believed, is primarily responsible for conversion of leukotriene C(4) to leukotriene D(4), the most potent of the cysteinyl leukotrienes and the immediate precursor of leukotriene E(4). GGL is a glycoprotein consisting of two polypeptide chains encoded by one gene and is attached at the amino terminus of the heavy chain to endothelial cell membranes. In mice it localizes to capillaries and sinusoids in most organs and in lung to larger vessels as well. In contrast to wild-type and GGT-deficient mice, GGL-deficient mice do not form leukotriene D(4) in vivo either in blood when exogenous leukotriene C(4) is administered intravenously or in bronchoalveolar lavage fluid of Aspergillus fumigatus extract-induced experimental asthma. Further, GGL-deficient mice show leukotriene C(4) accumulation and significantly more airway hyperreponsiveness than wild-type mice in the experimental asthma, and induction of asthma results in increased GGL protein levels and enzymatic activity. Thus GGL plays an important role in leukotriene D(4) synthesis in vivo and in inflammatory processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.