ArticleThe American journal of pathology2002
Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 114 citations in OpenAlex.
- The effect of parenteral betanin pre-treatment on the inflammatory response and proliferative activity of pulmonary parenchyma after jejunal ischaemia-reperfusion injury.Journal of veterinary research · 2025Article
- Modulation of COX-2 and NADPH oxidase-4 by alpha-lipoic acid ameliorates busulfan-induced pulmonary injury in rats.Heliyon · 2021Article
- Lipid Mediators Regulate Pulmonary Fibrosis: Potential Mechanisms and Signaling Pathways.International journal of molecular sciences · 2020Review
- Cytosolic phospholipase A2 contributes to innate immune defense against Candida albicans lung infection.BMC immunology · 2016Article
- Altered Cyclooxygenase-2 Expression in Pulmonary Sarcoidosis is not Related to Clinical Classifications.Inflammation · 2016Article
- Regulation of myofibroblast differentiation by cardiac glycosides.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.Clinical science (London, England : 1979) · 2016Article
- Contribution of alveolar type II cell-derived cyclooxygenase-2 to basal airway function, lung inflammation, and lung fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Cytosolic phospholipase A₂: physiological function and role in disease.Journal of lipid research · 2015Review
- Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis.PloS one · 2015Article
- Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2015Article
- Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A.The Journal of biological chemistry · 2014Article
- Evaluation of the Effects of Caffeic Acid Phenethyl Ester on Prostaglandin E2 and Two Key Cytokines Involved in Bleomycin-induced Pulmonary Fibrosis.Iranian journal of basic medical sciences · 2013Article
- Lung myofibroblasts are characterized by down-regulated cyclooxygenase-2 and its main metabolite, prostaglandin E2.PloS one · 2013Article
- Novel biphasic role of resolvin D1 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts is partly through PI3K/AKT and ERK2 pathways.Mediators of inflammation · 2013Article
- The clinical and immunologic features of pulmonary fibrosis in sarcoidosis.Translational research : the journal of laboratory and clinical medicine · 2012Article
- The role of cyclooxygenase-2 in mechanical ventilation-induced lung injury.American journal of respiratory cell and molecular biology · 2012Article
- Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages.Particle and fibre toxicology · 2012Article
- Lipopolysaccharide-induced cyclooxygenase-2 expression in mouse transformed Clara cells.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2012Article
- Prostaglandin E₂ protects murine lungs from bleomycin-induced pulmonary fibrosis and lung dysfunction.American journal of physiology. Lung cellular and molecular physiology · 2011Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
The cyclooxygenase (COX)-2 enzyme has been implicated as an important mediator of pulmonary fibrosis. In this study, the lung fibrotic responses were investigated in COX-1 or COX-2-deficient (-/-) mice following vanadium pentoxide (V(2)O(5)) exposure. Lung histology was normal in saline-instilled wild-type and COX-deficient mice. COX-2(-/-), but not COX-1(-/-) or wild-type mice, exhibited severe inflammatory responses by 3 days following V(2)O(5) exposure and developed pulmonary fibrosis 2 weeks post-V(2)O(5) exposure. Western blot analysis and immunohistochemistry showed that COX-1 protein was present in type 2 epithelial cells, bronchial epithelial cells, and airway smooth muscle cells of saline or V(2)O(5)-exposed wild-type and COX-2(-/-) mice. COX-2 protein was present in Clara cells of wild-type and COX-1(-/-) terminal bronchioles and was strongly induced 24 hours after V(2)O(5) exposure. Prostaglandin (PG) E(2) levels in the bronchoalveolar lavage (BAL) fluid from wild-type and COX-1(-/-) mice were significantly up-regulated by V(2)O(5) exposure within 24 hours, whereas PGE(2) was not up-regulated in COX-2(-/-) BAL fluid. Tumor necrosis factor-alpha was elevated in the BAL fluid from all genotypes after V(2)O(5) exposure, but was significantly and chronically elevated in the BAL fluid from COX-2(-/-) mice above wild-type or COX-1(-/-) mice. These findings indicate that the COX-2 enzyme is protective against pulmonary fibrogenesis, and we suggest that COX-2 generation of PGE(2) is an important factor in resolving inflammation.
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Registered trials
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