ArticleBritish journal of pharmacology2002
Sphingosine 1-phosphate enhances spontaneous transmitter release at the frog neuromuscular junction.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Effects of milk fat globule membrane ingestion with exercise on physical strength in healthy young adults: a randomized double-blind, placebo-controlled trial.Journal of the International Society of Sports Nutrition · 2025Trial
- Dietary sphingolipids and milk fat globule membrane: emerging roles in cardiometabolic health and muscle function.Food science and biotechnology · 2025Review
- The sphingosine-1-phosphate signaling pathway (sphingosine-1-phosphate and its receptor, sphingosine kinase) and epilepsy.Epilepsia open · 2025Review
- The SphK1/S1P Axis Regulates Synaptic Vesicle Endocytosis via TRPC5 Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Role of sphingolipid metabolism in neurodegeneration.Journal of neurochemistry · 2021Review
- Extracellular and intracellular sphingosine-1-phosphate distinctly regulates exocytosis in chromaffin cells.Journal of neurochemistry · 2019Article
- Sphingosine 1-Phosphate Receptors and Metabolic Enzymes as Druggable Targets for Brain Diseases.Frontiers in pharmacology · 2019Review
- Sphingolipids in neurodegeneration (with focus on ceramide and S1P).Advances in biological regulation · 2018Review
- Loss of Sphingosine Kinase Alters Life History Traits and Locomotor Function inFrontiers in genetics · 2017Article
- Diacylglycerol, phosphatidic acid, and their metabolic enzymes in synaptic vesicle recycling.Advances in biological regulation · 2015Review
- Extrasynaptic muscarinic acetylcholine receptors on neuronal cell bodies regulate presynaptic function in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release.Genes & development · 2012Article
- Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer.Nature reviews. Urology · 2011Review
- Permissive role of sphingosine on calcium-dependent endocytosis in chromaffin cells.Pflugers Archiv : European journal of physiology · 2010Article
- Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis.Neuron · 2009Article
- Antinociceptive activity of the S1P-receptor agonist FTY720.Journal of cellular and molecular medicine · 2008Article
- Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP).The Biochemical journal · 2003Article
- The vasoactive peptide urotensin II stimulates spontaneous release from frog motor nerve terminals.British journal of pharmacology · 2003Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Intracellular recordings were made from isolated frog sciatic-sartorius nerve-muscle preparations, and the effects of sphingosine 1-phosphate (S1-P) on miniature endplate potentials (MEPPs) were studied. Extracellular application of S1-P (1 and 30 micro M) had no significant effects on the frequency and amplitude of MEPPs. Delivery into nerve terminals by liposomes containing 10(-5), 10(-4) or 10(-3) M S1-P was associated with a concentration-dependent increase in MEPP frequency of 37, 63 and 86%. The per cent of median MEPP amplitude was not significantly changed, but there was an increase in the number of 'giant' MEPPs. Pre-exposure of the preparations to S1-P 10(-5) but not 10(-8) M entrapped in liposomes for 15 min blocked the effects of subsequent superfusion of S1-P (10(-4) M)-filled liposomes on MEPP frequency. Thus, intracellular S1-P receptors seem to undergo 'desensitization' to higher concentrations of S1-P. The result provides the first evidence that S1-P acting intracellularly but not extracellularly enhances spontaneous transmitter release at the frog neuromuscular junction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.