ArticleBiochemical and biophysical research communications2002
Cell-specific phosphorylation of Zfhep transcription factor.
Article in Biochemical and biophysical research communications, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- ERK2-mediated phosphorylation of ZEB1 at S322 enhances PD-L1 expression and EMT, leading to pancreatic cancer progression.Cell communication and signaling : CCS · 2025Article
- Zeb1 facilitates corneal epithelial wound healing by maintaining corneal epithelial cell viability and mobility.Communications biology · 2023Article
- An Overview of Epithelial-to-Mesenchymal Transition and Mesenchymal-to-Epithelial Transition in Canine Tumors: How Far Have We Come?Veterinary sciences · 2022Review
- The Post-Translational Regulation of Epithelial-Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis.International journal of molecular sciences · 2021Review
- PKCα Modulates Epithelial-to-Mesenchymal Transition and Invasiveness of Breast Cancer Cells Through ZEB1.Frontiers in oncology · 2019Article
- ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma Progression.Scientific reports · 2017Article
- Phosphorylation Regulates Functions of ZEB1 Transcription Factor.Journal of cellular physiology · 2016Article
- Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition.The Journal of biological chemistry · 2014Article
- Regulation of C. elegans neuronal differentiation by the ZEB-family factor ZAG-1 and the NK-2 homeodomain factor CEH-28.PloS one · 2014Article
- EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness.Cellular and molecular life sciences : CMLS · 2012Review
- Evolutionary functional analysis and molecular regulation of the ZEB transcription factors.Cellular and molecular life sciences : CMLS · 2012Review
- Metastatic progression of prostate cancer and e-cadherin regulation by zeb1 and SRC family kinases.The American journal of pathology · 2011Article
- TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition.The EMBO journal · 2011Article
- Expanding roles of ZEB factors in tumorigenesis and tumor progression.American journal of cancer research · 2011Article
- ZEB1 coordinately regulates laminin-332 and {beta}4 integrin expression altering the invasive phenotype of prostate cancer cells.The Journal of biological chemistry · 2010Article
- ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells.Molecular biology of the cell · 2009Article
- The zinc finger transcription factor ZFHX1A is linked to cell proliferation by Rb-E2F1.The Biochemical journal · 2007Article
- The ZFHX1A gene is differentially autoregulated by its isoforms.Biochemical and biophysical research communications · 2007Article
- Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells.American journal of human genetics · 2005Article
- Expression of Zfhep/deltaEF1 protein in palate, neural progenitors, and differentiated neurons.Gene expression patterns : GEP · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Zinc finger homeodomain enhancer-binding protein (Zfhep/Zfhx1a) is a transcription factor essential for immune system development, skeletal patterning, and life. Regulation of the interleukin-2 gene in T cells has been suggested to depend on post-translational processing of Zfhep, however, no modifications of Zfhep are known. Here we demonstrate that Zfhep is present in both hyperphosphorylated and hypophosphorylated forms. Western blot analysis demonstrates two forms of Zfhep with different mobilities. Differences in phosphorylation are sufficient to explain the difference in mobilities. Zfhep is primarily phosphorylated on Ser and Thr residues since PP2A dephosphorylates the slower mobility band. Treatment of nuclear extract with O-GlcNAcase did not detect O-linked sugar. Importantly, post-translational processing is cell-specific. Doublets of Zfhep were detected in five cell lines, whereas 6 cell lines contain only, or predominantly, non-phosphorylated Zfhep, and Saos-2 cells contain predominantly the phosphorylated form. These data provide the first demonstration that Zfhep is post-translationally modified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.