ArticleMolecular and cellular biochemistry
Differential role of hydrogen peroxide in UV-induced signal transduction.
Article in Molecular and cellular biochemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Peroxiredoxin V Protects against UVB-Induced Damage of Keratinocytes.Antioxidants (Basel, Switzerland) · 2023Article
- Indole Hydrazide Compound IHZ-1 Induces Apoptosis and AutophagyFrontiers in oncology · 2022Article
- Counteracting the Ramifications of UVB Irradiation and Photoaging withMolecules (Basel, Switzerland) · 2021Article
- Unexpected dose response of HaCaT to UVB irradiation.In vitro cellular & developmental biology. Animal · 2018Article
- Advances in revealing the molecular targets downstream of oxidative stress-induced proapoptotic kinase signaling in diabetic embryopathy.American journal of obstetrics and gynecology · 2015Review
- A novel post-translational modification of nucleolin, SUMOylation at Lys-294, mediates arsenite-induced cell death by regulating gadd45α mRNA stability.The Journal of biological chemistry · 2015Article
- Co-translational mechanisms of quality control of newly synthesized polypeptides.Translation (Austin, Tex.) · 2014Review
- Modulatory effect of phytoglycoprotein (38 kDa) on cyclin D1/CDK4 in BNL CL.2 cells induced by N-methyl-N'-nitro-N-nitrosoguanidine.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
- mTOR signaling in protein homeostasis: less is more?Cell cycle (Georgetown, Tex.) · 2011Review
- Effect of novel marine nutraceuticals on IL-1α-mediated TNF-α release from UVB-irradiated human melanocyte-derived cells.Oxidative medicine and cellular longevity · 2011Article
- mTORC1 links protein quality and quantity control by sensing chaperone availability.The Journal of biological chemistry · 2010Article
- PGF2alpha-associated vascular smooth muscle hypertrophy is ROS dependent and involves the activation of mTOR, p70S6k, and PTEN.Prostaglandins & other lipid mediators · 2008Article
- Inhibition of UVA-induced apoptotic signaling pathway by polypeptide from Chlamys farreri in human HaCaT keratinocytes.Radiation and environmental biophysics · 2007Article
- Stress and mTORture signaling.Oncogene · 2006Review
- Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Electrolyzed Reduced Water Supplemented with Platinum Nanoparticles Suppresses Promotion of Two-stage Cell Transformation.Cytotechnology · 2005Article
- Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells.Oncogene · 2003Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigated the differential requirement of ROS in UV-induced activation of these pathways. Exposure of the mouse epidermal C141 cells to UV radiation led to generation of ROS as measured by electron spin resonance (ESR) and by H2O2 and O2. fluorescence staining assay. Treatment of cells with UV radiation or H2O2 also markedly activated Erks, JNKs, p38 kinase and led to increases in phosphorylation of Akt and p70(S6k) in mouse epidermal JB6 cells. The scavenging of UV-generated H2O2 by N-acety-L-cyteine (NAC, a general antioxidant) or catalase (a specific H2O2 inhibitor) inhibited UV-induced activation of JNKs, p38 kinase, Akt and p70(S6k), while it did not show any inhibitory effects on Erks activation. Further, pretreatment of cells with sodium formate (an .OH radical scavenger) or superoxide dismutase (O2-. radical scavenger) did not inhibit any of these pathways. These results demonstrate that H2O2 generation is required for UV-induced phosphorylation of Akt and p70(S6k), and involved in activation of JNKs and p38 kinase, but not Erks.
Indexed as
Identifiers
12162463W1591526813What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.