ReviewMolecular and cellular biochemistry
Molecular mechanisms of Cr(VI)-induced carcinogenesis.
Review in Molecular and cellular biochemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Photocatalytic reduction of aqueous chromium(vi) by RuORSC advances · 2025Article
- Oxidative, epigenetic changes and fermentation processes in the intestine of rats fed high-fat diets supplemented with various chromium forms.Scientific reports · 2022Article
- Current understanding of hexavalent chromium [Cr(VI)] neurotoxicity and new perspectives.Environment international · 2022Review
- Case Report: Two Cases of Salivary Duct Carcinoma in Workers With a History of Chromate Exposure.Frontiers in medicine · 2021Article
- Hexavalent chromium-induced autophagic death of WRL-68 cells is mitigated by aqueous extract of3 Biotech · 2020Article
- Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells.Toxicology and applied pharmacology · 2017Article
- Toxicity and oxidative stress induced by chromium in workers exposed from different occupational settings around the globe: A review.Environmental science and pollution research international · 2016Review
- Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells.Oncotarget · 2016Article
- Temporal changes in rat liver gene expression after acute cadmium and chromium exposure.PloS one · 2015Article
- Differential responses to genotoxic agents between induced pluripotent stem cells and tumor cell lines.Journal of hematology & oncology · 2013Article
- Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3β/β-catenin signaling.Toxicology and applied pharmacology · 2013Article
- Hexavalent chromium-induced alteration of proteomic landscape in human skin fibroblast cells.Journal of proteome research · 2013Article
- Antigenotoxic and apoptotic activity of green tea polyphenol extracts on hexavalent chromium-induced DNA damage in peripheral blood of CD-1 mice: analysis with differential acridine orange/ethidium bromide staining.Oxidative medicine and cellular longevity · 2013Article
- Surface-enhanced Raman imaging of intracellular bioreduction of chromate in Shewanella oneidensis.PloS one · 2011Article
- The dual roles of c-Jun NH2-terminal kinase signaling in Cr(VI)-induced apoptosis in JB6 cells.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Antioxidant Activity of Lawsonia inermis Extracts Inhibits Chromium(VI)-Induced Cellular and DNA Toxicity.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Chromium genotoxicity: A double-edged sword.Chemico-biological interactions · 2010Review
- Compartment-specific enhancement of white matter and nerve ex vivo using chromium.Magnetic resonance in medicine · 2010Article
- Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells.Toxicology and applied pharmacology · 2010Article
- Chromium reduces the in vitro activity and fidelity of DNA replication mediated by the human cell DNA synthesome.Toxicology and applied pharmacology · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Cr(VI)-containing compounds are well documented carcinogens, their mechanism of action is still not well understood. Recent studies have suggested that reduction of Cr(VI) to its lower oxidation states and related free radical reactions play an important role in Cr(VI)-induced carcinogenesis. This article summarizes recent studies from our laboratory on (a) the reduction of Cr(VI) by ascorbate, diol- and thiol-containing molecules, certain flavoenzymes, cell organelles, intact cells, and whole animals; (b) free radical production in both non-cellular and cellular systems; and (c) Cr(VI)-induced DNA damage, activation of nuclear transcription factor KB (NF-kappaB), activator protein-1, p53, hypoxia-inducible factor-1, vascular endothelial growth factor, tyrosine phosphorylation, apoptosis, cell growth arrest, and gene expression profile.
Indexed as
Identifiers
12162446What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.