ArticleMolecular and cellular biochemistry
Involvement of hydrogen peroxide in asbestos-induced NFAT activation.
Article in Molecular and cellular biochemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
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- Understanding chronic inflammation: couplings between cytokines, ROS, NO, CaFrontiers in immunology · 2025Review
- Crucial role of c-Jun phosphorylation at Ser63/73 mediated by PHLPP protein degradation in the cheliensisin a inhibition of cell transformation.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.Stem cells (Dayton, Ohio) · 2014Article
- Ectopic overexpression of haem oxygenase-1 protects kidneys from carboplatin-mediated apoptosis.British journal of pharmacology · 2011Article
- Developing a Deeper Understanding of Autism: Connecting Knowledge through Literature Mining.Autism research and treatment · 2011Article
- Activation of a nuclear factor of activated T-lymphocyte-3 (NFAT3) by oxidative stress in carboplatin-mediated renal apoptosis.British journal of pharmacology · 2010Article
- Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes.Molecular carcinogenesis · 2008Article
- Mechanisms of noise-induced hearing loss indicate multiple methods of prevention.Hearing research · 2007Review
- Article
- Hydrogen peroxide as a diffusible signal molecule in synaptic plasticity.Molecular neurobiology · 2004Review
- Paradoxical actions of hydrogen peroxide on long-term potentiation in transgenic superoxide dismutase-1 mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The present study investigated the role of reactive oxygen species (ROS) in activation of nuclear factor of activated T cells (NFAT), a pivotal transcription factor responsible for regulation of cytokines, by asbestos in mouse embryo fibroblast PW cells. Exposure of cells to asbestos led to the transactivation of NFAT in a time- and dose-dependent manner. Scavenging of asbestos-induced H2O2 with N-acety-L-cyteine (NAC, a general antioxidant) or catalase (a specific H2O2 inhibitor) resulted in inhibition of NFAT activation. In contrast, an increase in H2O2 generation by the addition of superoxide dismutase (SOD) slightly enhanced asbestos-induced NFAT activation. In addition, pretreatment of cells with sodium formate did not exhibit any inhibition of NFAT activity induced by asbestos. These results demonstrated that H2O2 appeared to play an important role in asbestos-induced NFAT transactivation. Furthermore, it was observed that incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) not only resulted in NFAT activation by itself, but also enhanced asbestos-induced NFAT induction. Pretreatment of cells with cyclosporin A (CSA), a pharmacological inhibitor of the phosphatase calcineurin, blocked both asbestos- and TPA plus asbestos-induced NFAT activation. These data suggest that asbestos is able to induce NFAT activation through H2O2-dependent and CSA-sensitive pathways, which may be involved in asbestos-induced carcinogenesis.
Indexed as
Identifiers
12162429W1561291777What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.