ArticleThe Journal of physiology2002
Exercise-induced increase in interstitial bradykinin and adenosine concentrations in skeletal muscle and peritendinous tissue in humans.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 113 citations in OpenAlex.
- The Effect of Acute Beetroot Juice and Caffeine Supplementation on Specific Judo Performance During a Simulated Competition Day in Judo Athletes.European journal of sport science · 2026Trial
- Combined inhibition of nitric oxide and prostaglandins reduces human skeletal muscle blood flow during exercise.The Journal of physiology · 2002Trial
- Association of muscle instability and long-term prophylaxis in hereditary angioedema.The World Allergy Organization journal · 2026Article
- Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness.The journal of physiological sciences : JPS · 2024Review
- KAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) expression in arterioles supplying skeletal and cardiac muscles and in arterioles feeding some murine organs.Histochemistry and cell biology · 2021Article
- Effects of bradykinin on voltage-gated KThe Journal of physiology · 2021Article
- KJournal of neurophysiology · 2021Article
- Recovery From Repeat Mild Traumatic Brain Injury in Adolescent Rats Is Dependent on Pre-injury Activity State.Frontiers in neurology · 2020Article
- Marker Expression of Interstitial Cells in Human Skeletal Muscle: An Immunohistochemical Study.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- Psychophysiological Stress Response of a Paralympic Athlete During an Ultra-Endurance Event. A Case Study.Journal of medical systems · 2019Article
- TRPV1 and BDKRB2 receptor polymorphisms can influence the exercise pressor reflex.The Journal of physiology · 2018Article
- Preconditioning Contractions Suppress Muscle Pain Markers after Damaging Eccentric Contractions.Pain research & management · 2018Article
- Effects of exercise training on nitric oxide, blood pressure and antioxidant enzymes.Journal of clinical biochemistry and nutrition · 2017Article
- Exercise and NO production: relevance and implications in the cardiopulmonary system.Frontiers in cell and developmental biology · 2014Review
- Bradykinin B2 receptor contributes to the exaggerated muscle mechanoreflex in rats with femoral artery occlusion.American journal of physiology. Heart and circulatory physiology · 2013Article
- Transient receptor potentials (TRPs) and anaphylaxis.Current allergy and asthma reports · 2013Review
- Postexercise skeletal muscle glucose transport is normal in kininogen-deficient rats.Medicine and science in sports and exercise · 2011Article
- The kallikrein-kinin system as a regulator of cardiovascular and renal function.Comprehensive Physiology · 2011Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bradykinin is known to cause vasodilatation in resistance vessels and may, together with adenosine, be an important regulator of tissue blood flow during exercise. Whether tissue concentrations of bradykinin change with exercise in skeletal muscle and tendon-related connective tissue has not yet been established. Microdialysis (molecular mass cut-off 5 kDa) was performed simultaneously in calf muscle and peritendinous Achilles tissue at rest and during 10 min periods of incremental (0.75 W, 2 W, 3.5 W and 4.75 W) dynamic plantar flexion exercise in 10 healthy individuals (mean age 27 years, range 22-33 years). Interstitial bradykinin and adenosine concentrations were determined using an internal reference to determine relative recovery ([2,3,prolyl-3,4-(3)H(N)]-bradykinin and [2-(3)H]-adenosine). Bradykinin and adenosine recovery were closely related and in the range of 30-50 %. The interstitial concentration of bradykinin rose in response to exercise both in skeletal muscle (from 23.1 +/- 4.9 nmol l(-1) to 110.5 +/- 37.9 nmol l(-1); P < 0.05) and in the peritendinous tissue (from 27.7 +/- 7.8 nmol l(-1) to 105.0 +/- 37.9 nmol l(-1); P < 0.05). In parallel, the adenosine concentration increased both in muscle (from 0.48 +/- 0.07 micromol l(-1) to 1.59 +/- 0.35 micromol l(-1); P < 0.05) and around the tendon (from 0.33 +/- 0.03 micromol l(-1) to 0.86 +/- 0.16 micromol l(-1); P < 0.05). In conclusion, the data show that muscular activity increases the interstitial concentrations of bradykinin and adenosine in both skeletal muscle and the connective tissue around its adjacent tendon. These findings support a role for bradykinin and adenosine in exercise-induced hyperaemia in skeletal muscle and suggest that bradykinin and adenosine are potential regulators of blood flow in peritendinous tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.