ArticleThe Journal of physiology2002
Properties of spontaneously active cells distributed in the submucosal layer of mouse proximal colon.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Burst-patterned stimulation restores colonic motility in preclinical models.Science translational medicine · 2025Article
- CaPhysiological reviews · 2024Review
- Calcium image analysis in the moving gut.Neurogastroenterology and motility · 2023Article
- Current applications of mathematical models of the interstitial cells of Cajal in the gastrointestinal tract.WIREs mechanisms of disease · 2021Review
- CaeLife · 2021Article
- Expression of the regulated isoform of the electrogenic NaAmerican journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Relationships Between Distention-, Butyrate- and Pellet-Induced Stimulation of Peristalsis in the Mouse Colon.Frontiers in physiology · 2020Article
- First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.Nature reviews. Gastroenterology & hepatology · 2019Review
- CaThe Journal of physiology · 2019Article
- Spontaneous Electrical Activity and Rhythmicity in Gastrointestinal Smooth Muscles.Advances in experimental medicine and biology · 2019Review
- The effects of mitochondrial inhibitors on CaCell calcium · 2018Article
- Article
- A model of the enteric neural circuitry underlying the generation of rhythmic motor patterns in the colon: the role of serotonin.American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon.Journal of neurogastroenterology and motility · 2016Article
- Colonic migrating motor complexes, high amplitude propagating contractions, neural reflexes and the importance of neuronal and mucosal serotonin.Journal of neurogastroenterology and motility · 2014Article
- Effects of feeding on in vivo motility patterns in the proximal intestine of shorthorn sculpin (Myoxocephalus scorpius).The Journal of experimental biology · 2014Article
- The significance of interstitial cells in neurogastroenterology.Journal of neurogastroenterology and motility · 2014Article
- Two independent networks of interstitial cells of cajal work cooperatively with the enteric nervous system to create colonic motor patterns.Frontiers in neuroscience · 2011Article
- Biophysically based modeling of the interstitial cells of cajal: current status and future perspectives.Frontiers in physiology · 2011Article
- Ca2+ imaging of activity in ICC-MY during local mucosal reflexes and the colonic migrating motor complex in the murine large intestine.The Journal of physiology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular electrical activity was recorded from smooth muscle tissues of the mouse proximal colon, and the impaled cells were visualized by injection of neurobiotin. Slow potentials with initial fast and subsequent plateau components (plateau potentials), generated at a frequency of 14.8 min(-1), were recorded from oval-shaped cells with bipolar processes. Periodic bursts of spike potentials (4.6 min(-1)) and bursts of oscillatory potentials (4.3 min(-1)) were recorded in circular and longitudinal smooth muscle cells, respectively. Nifedipine (0.1 microM) abolished the bursts of spike and oscillatory potentials and reduced the duration of plateau potentials. The plateau potentials were abolished by 1 microM nifedipine. The plateau potentials were also abolished by cyclopiazonic acid (an inhibitor of Ca(2+) uptake into internal stores) or 2-aminoethoxydiphenyl borate (an inhibitor of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release), and were inhibited by bis-(aminophenoxy) ethane-N,N,N,'N'-tetraacetic acid acetoxymethyl ester (a chelator of intracellular Ca(2+)). Carbonyl cyanide m-chlorophenylhydrazone (a mitochondrial protonophore) abolished plateau potentials, and its action was not mimicked by oligomycin (an inhibitor of mitochondrial ATPase). It is concluded that in mouse proximal colon, submucosal c-kit-positive bipolar cells spontaneously generate plateau potentials with rhythms different from those generated by smooth muscle cells. The plateau potentials are generated through activation of voltage-gated Ca(2+) channels, which are coupled to the release of Ca(2+) from the internal stores and the handling of Ca(2+) in mitochondria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.