ArticleGenes & development2002
Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination.
Article in Genes & development, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 72 citations in OpenAlex.
- A novelBlood · 2019Article
- Physiological Roles of DNA Double-Strand Breaks.Journal of nucleic acids · 2017Review
- RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair.Nature communications · 2016Article
- Article
- V(D)J Recombination: Mechanism, Errors, and Fidelity.Microbiology spectrum · 2014Review
- RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.Cell reports · 2013Article
- Role of non-homologous end joining in V(D)J recombination.Immunologic research · 2012Review
- Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.Nucleic acids research · 2012Article
- The response to and repair of RAG-mediated DNA double-strand breaks.Annual review of immunology · 2012Review
- Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid binding.BMC biochemistry · 2011Article
- Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency.The Journal of experimental medicine · 2010Article
- Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.Nucleic acids research · 2010Article
- RAG: a recombinase diversified.Nature immunology · 2009Review
- H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.Molecular cell · 2009Article
- Full-length RAG1 promotes contact with coding and intersignal sequences in RAG protein complexes bound to recombination signals paired in cis.Nucleic acids research · 2009Article
- Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.Blood · 2009Article
- A biochemically defined system for coding joint formation in V(D)J recombination.Molecular cell · 2008Article
- DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis.Immunologic research · 2008Review
- The structure-specific nicking of small heteroduplexes by the RAG complex: implications for lymphoid chromosomal translocations.DNA repair · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
In addition to creating the DNA double strand breaks that initiate V(D)J recombination, the RAG proteins are thought to play a critical role in the joining phase of the reaction. One such role, suggested by in vitro studies, might be to ensure the structural integrity of postcleavage complexes, but the significance of such a function in vivo is unknown. We have identified RAG1 mutants that are proficient in DNA cleavage but defective in their ability to interact with coding ends after cleavage and in the capture of target DNA for transposition. As a result, these mutants exhibit severe defects in hybrid joint formation, hairpin coding end opening, and transposition in vitro, and in V(D)J recombination in vivo. Our results suggest that the RAG proteins have an architectural function in facilitating proper and efficient V(D)J joining, and a protective function in preventing degradation of broken ends prior to joining.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.