ArticleEnvironmental health perspectives2002
Evidence of reproductive endocrine effects in women with occupational fuel and solvent exposures.
Article in Environmental health perspectives, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Understanding the Endocrine and Reproductive Health Effects Associated With Exposures to Jet Fuels: A Fit-for-Purpose Systematic Literature Review.Journal of occupational and environmental medicine · 2026Pooled it
- Occupational Exposure to Benzene and Risk of Breast Cancer: Systematic Review and Meta-Analysis.La Medicina del lavoro · 2024Pooled it
- Morbidities Associated with Drinking Water Contamination After a 2021 Petroleum Leak - Oahu, Hawaii, March 2023.Disaster medicine and public health preparedness · 2025Article
- Environmental and occupational risks to reproductive health in women service members and veterans.Frontiers in public health · 2025Review
- Article
- Dietary Supplementation of Flaxseed (Life (Basel, Switzerland) · 2022Article
- Toxicological Effects of Technical Xylene Mixtures on the Female Reproductive System: A Systematic Review.Toxics · 2022Review
- Hormonal Profiles of Menstrual Bleeding Patterns During the Luteal-Follicular Transition.The Journal of clinical endocrinology and metabolism · 2020Article
- Polybrominated Biphenyl Exposure and Menstrual Cycle Function.Epidemiology (Cambridge, Mass.) · 2019Article
- Assessing effects of germline exposure to environmental toxicants by high-throughput screening in C. elegans.PLoS genetics · 2019Article
- Health Risk Associated with Exposure to PMInternational journal of environmental research and public health · 2018Article
- Occupational exposure to carcinogens: Benzene, pesticides and fibers (Review).Molecular medicine reports · 2016Review
- Menstrual cycle perturbation by organohalogens and elements in the Cree of James Bay, Canada.Chemosphere · 2016Article
- A review of environmental and occupational exposure to xylene and its health concerns.EXCLI journal · 2015Review
- Breast cancer risk after occupational solvent exposure: the influence of timing and setting.Cancer research · 2014Article
- Identification of genomic features in environmentally induced epigenetic transgenerational inherited sperm epimutations.PloS one · 2014Article
- Evaluating the effects of maternal exposure to benzene, toluene, ethyl benzene, and xylene on oral clefts among offspring in Texas: 1999-2008.Birth defects research. Part A, Clinical and molecular teratology · 2013Article
- Antimüllerian hormone as a predictor of natural fecundability in women aged 30-42 years.Obstetrics and gynecology · 2011Article
- Occupational risk factors for endometrial cancer among textile workers in Shanghai, China.American journal of industrial medicine · 2008Article
- The value of home-based collection of biospecimens in reproductive epidemiology.Environmental health perspectives · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Hydrocarbons (HCs) found in fuels and solvents are ubiquitous in the environment, yet we know little about their effects on the endocrine system. The objective of this study was to assess the potential reproductive endocrine effects of low-dose HCs encountered by female U.S. Air Force personnel with fuel (primarily JP-8 jet fuel) and solvent exposures (n = 63). We estimated the internal dose of HCs in fuels and solvents by measuring their levels in exhaled breath, including the sum of aliphatic HCs (C6H14-C16H34) and the sum of aromatic HCs (benzene, ethylbenzene, toluene, and m,p,o-xylenes). Adverse outcome measures included urinary endocrine markers that have been associated with nonconceptive (vs. conceptive) menstrual cycles in ovulatory women: lower preovulatory luteinizing hormone (LH) and mid-luteal phase pregnanediol 3-glucuronide (Pd3G) and estrone 3-glucuronide, and higher follicle phase Pd3G. We also obtained reproductive and exposure information from baseline questionnaires and daily diaries. Toluene was the most frequently found analyte in the breath, with values up to 52.0 ppb, and benzene breath levels were up to 97.5 ppb. Regression analysis revealed that preovulatory LH levels were significantly lower (p = 0.007) among women whose total aliphatic HC levels were above the median. The relationship between elevated aliphatic HC exposure and lowered preovulatory LH levels in the present study suggests that compounds in fuels and some solvents may act as reproductive endocrine disruptors. Confirmation of these findings is needed, not only to determine if fuel and solvent exposure may impact other LH-dependent physiologic functions but also to examine effects of fuels and solvents on conception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.