ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Orexin-A depolarizes dissociated rat area postrema neurons through activation of a nonselective cationic conductance.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 68 citations in OpenAlex.
- Orexin and MCH neurons: regulators of sleep and metabolism.Frontiers in neuroscience · 2023Review
- Orexin-A Intensifies Mouse Pupillary Light Response by Modulating Intrinsically Photosensitive Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Orexin Depolarizes Central Amygdala Neurons via Orexin Receptor 1, Phospholipase C and Sodium-Calcium Exchanger and Modulates Conditioned Fear.Frontiers in neuroscience · 2018Article
- Hypocretin/Orexin Peptides Excite Rat Neuroendocrine Dopamine Neurons through Orexin 2 Receptor-Mediated Activation of a Mixed Cation Current.Scientific reports · 2017Article
- Physiological roles for the subfornical organ: a dynamic transcriptome shaped by autonomic state.The Journal of physiology · 2016Review
- The Neurobiology of Sleep and Wakefulness.The Psychiatric clinics of North America · 2015Review
- Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats.Neuropharmacology · 2015Article
- Calcium affects OX1 orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery.British journal of pharmacology · 2014Article
- Orexin/hypocretin receptor signalling: a functional perspective.British journal of pharmacology · 2014Article
- Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far.Frontiers in neuroscience · 2013Review
- Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy.Frontiers in neuroscience · 2013Article
- Evidence for the role of hindbrain orexin-1 receptors in the control of meal size.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Orexin-A hyperphagia: hindbrain participation in consummatory feeding responses.Endocrinology · 2009Article
- Dual orexin actions on dorsal raphe and laterodorsal tegmentum neurons: noisy cation current activation and selective enhancement of Ca2+ transients mediated by L-type calcium channels.Journal of neurophysiology · 2008Article
- Area postrema neurons are modulated by the adipocyte hormone adiponectin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- The subfornical organ: a central target for circulating feeding signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Hypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Excitatory effects of orexin-A on nucleus tractus solitarius neurons are mediated by phospholipase C and protein kinase C.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Selective enhancement of synaptic inhibition by hypocretin (orexin) in rat vagal motor neurons: implications for autonomic regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The area postrema (AP) is involved in the regulation of body fluid balance, feeding behavior, and cardiovascular function. Orexin (ORX)-A is a 33 aa peptide that regulates energy metabolism and sympathetic and cardiovascular actions. ORX immunoreactive axons and their varicose terminals have been found in AP. In this study, whole-cell, current- or voltage-clamp recordings were obtained from 108 dissociated rat AP neurons. The mean resting membrane potential of these neurons (n = 48) was -59.24 +/- 0.87 mV, the mean input resistance was 3.57 +/- 0.22 G(Omega), and the action potential amplitude of these cells was always >90 mV. Current-clamp studies showed bath application of ORX-A depolarized the majority of AP neurons tested (68.8%; 33 of 48), whereas small proportions of cells were either hyperpolarized (16.7%; 8 of 48) or unaffected (14.6%; 7 of 48). These depolarizing effects were found to be concentration dependent from 10(-8) to 10(-11) m. We then examined the contributions of specific ionic conductances to the ORX-A-induced excitation of AP neurons through whole-cell, voltage-clamp studies. Our results demonstrate that in contrast to previous studies on other neuronal populations, ORX-A did not affect net whole-cell potassium currents in AP neurons. Slow depolarizing voltage ramps, however, revealed that ORX-A enhanced a nonselective cationic conductance in AP neurons, effects which would explain the depolarizing effects of the peptide. These data demonstrate that AP neurons are directly influenced by ORX-A and suggest that ORX-A may exert its effects on the central control of feeding behavior and cardiovascular function through direct actions in AP.
Indexed as
Identifiers
12151505PMC6758169W2122196568What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.