ArticleThorax2002
Respiratory medications and risk of asthma death.
Article in Thorax, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- The use of electronic alerts in primary care computer systems to identify the excessive prescription of short-acting betaNPJ primary care respiratory medicine · 2018Pooled it
- Trial
- Short-term effects of inhaled salbutamol on autonomic cardiovascular control in healthy subjects: a placebo-controlled study.British journal of clinical pharmacology · 2009Trial
- Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma.Thorax · 2005Trial
- Haemodynamic responses to salbutamol and isometric exercise are altered in young adults with mild asthma.European journal of clinical pharmacology · 2005Trial
- Climate Change and the Switch from Pressurised Metered-Dose Inhalers to Dry Powder Inhalers: A Proportionate Balancing of Risk and Reward?Pulmonary therapy · 2026Review
- Reducing short-acting beta-agonist overprescribing in asthma: lessons from a quality-improvement prescribing project in East London.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Article
- Association of genetic variants with level of asthma control in the Arab population.Journal of asthma and allergy · 2019Article
- Prognostic nomogram for inpatients with asthma exacerbation.BMC pulmonary medicine · 2017Article
- Article
- Assessment of pediatric asthma drug use in three European countries; a TEDDY study.European journal of pediatrics · 2011Article
- Classifying asthma severity and treatment determinants: national guidelines revisited.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2008Review
- Distinguishing patterns in the dynamics of long-term medication use by Markov analysis: beyond persistence.BMC health services research · 2007Article
- Bronchodilator treatment and deaths from asthma: case-control study.BMJ (Clinical research ed.) · 2005Article
- Overcoming gaps in the management of asthma in older patients: new insights.Drugs & aging · 2005Review
- Categorizing asthma severity: an overview of national guidelines.Clinical medicine & research · 2004Review
- The dose-response relationship of inhaled corticosteroids in asthma.Current allergy and asthma reports · 2004Review
- A benefit-risk assessment of inhaled long-acting beta2-agonists in the management of obstructive pulmonary disease.Drug safety · 2004Review
- Inhaled salmeterol/fluticasone propionate combination: a pharmacoeconomic review of its use in the management of asthma.PharmacoEconomics · 2003Review
- Overview of the pharmacogenetics of asthma treatment.The pharmacogenomics journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of respiratory medications on risk of asthma death in the UK was studied using the General Practice Research Database.
methodsA total of 96 258 individuals with a diagnosis of asthma were identified, 43 of whom had died as a result of their asthma. For each case 20 controls were selected. Relative risk (RR) estimates and 95% confidence intervals (CI) were computed for each respiratory drug category controlling for effects of age, sex, body mass index, smoking, frequency of visits to the GP, hospital admissions for asthma, and visits to a specialist.
resultsThe strongest associations were found for at least 13 prescriptions of short acting beta agonists during the previous year (RR=51.6, 95% CI 7.9 to 345) and 7-12 prescriptions of short acting beta agonists (RR=16.2, 95% CI 2.6 to 101). Short acting beta agonists and inhaled steroids tended to be prescribed most frequently to the same patients. In patients who received more than one prescription per month of short acting beta agonists during the previous year, regular use of inhaled steroids was associated with a 60% reduced risk of asthma death (RR=0.4, 95% CI 0.2 to 1.0).
conclusionsRegular use of inhaled steroids is associated with a decreased risk of asthma death, and excessive use of short acting beta agonists is associated with a markedly increased risk of asthma death.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.