Evidence map›Paper›PMID 12149518›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2002

Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E(mu)-v-abl transgenic mice.

R C Andrew Symons, Mark J Daly, Jane Fridlyand, Terence P Speed, Wendy D Cook, Steven Gerondakis, Alan W Harris, Simon J Foote

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Statistical optimization of parametric accelerated failure time model for mapping survival trait loci.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011
    Article
  5. Genetic loci that control the size of laser-induced choroidal neovascularization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009
    Article
  6. Article
  7. Perforin-mediated suppression of B-cell lymphoma.Proceedings of the National Academy of Sciences of the United States of America · 2009
    Article
  8. Robust Bayesian mapping of quantitative trait loci using Student-t distribution for residual.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2009
    Article
  9. Article
  10. Article
  11. Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2006
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

R C Andrew SymonsThe Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia.
Mark J Daly
Jane Fridlyand
Terence P Speed
Wendy D Cook
Steven Gerondakis
Alan W Harris
Simon J Foote
The Royal Melbourne Hospital · AUWalter and Eliza Hall Institute of Medical Research · AU

Funding

Wellcome Trust
6 · The paper itself

Abstract

There is a great difference in susceptibility to v-abl transgene-induced plasmacytoma between the BALB/cAn and the relatively resistant C57BL/6J mouse strains. We have used the Mapmaker/SURVIVOR algorithm to analyze genome-wide scans on over 800 transgenic F2 hybrid mice, and have mapped at least six loci on chromosomes 2, 4, 11, 17, and 18 that modify tumor-related morbidity. As in human multiple myeloma, males were found to be more prone to plasmacytomagenesis. Different loci influence tumor susceptibility in male and female mice. Survival in females may be largely controlled by a pair of interacting loci on chromosomes 2 and 17.

Indexed as

Genes, ablGenetic Predisposition to DiseaseAlgorithmsAnimalsCrosses, GeneticDisease Models, AnimalFemaleGene Expression Regulation, NeoplasticGenetic LinkageGenotypeHumansMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred Strains

Identifiers

PMID12149518
PMCPMC123251
OpenAlexW2110606713

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.