Trial reportProceedings of the National Academy of Sciences of the United States of America2002
Increased peripheral expansion of naive CD4+ T cells in vivo after IL-2 treatment of patients with HIV infection.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 64 citations in OpenAlex.
- Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption: a randomized controlled trial.AIDS (London, England) · 2009Trial
- Immune reconstitution of CD56(dim) NK cells in individuals with primary HIV-1 infection treated with interleukin-2.The Journal of infectious diseases · 2008Trial
- Expansion of CD1d-restricted NKT cells in patients with primary HIV-1 infection treated with interleukin-2.Blood · 2006Trial
- In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients.The Journal of clinical investigation · 2005Trial
- β-glucans from Euglena gracilis or Saccharomyces cerevisiae effects on immunity and inflammatory parameters in dogs.PloS one · 2024Article
- Ex Vivo HIV Infection Model of Cervico-Vaginal and Rectal Tissue.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans.Aging cell · 2015Article
- Production of functional native human interleukin-2 in tobacco chloroplasts.Molecular biotechnology · 2014Article
- Mathematical Models of the Impact of IL2 Modulation Therapies on T Cell Dynamics.Frontiers in immunology · 2013Review
- T-cell activation by treatment of cancer patients with EMD 521873 (Selectikine), an IL-2/anti-DNA fusion protein.Journal of translational medicine · 2013Article
- Review
- Generation of heterogeneous memory T cells by live attenuated tularemia vaccine in humans.Vaccine · 2009Article
- Systemic administration of interleukin-2 inhibits inflammatory neutrophil migration: role of nitric oxide.British journal of pharmacology · 2006Article
- Naïve T-cell dynamics in human immunodeficiency virus type 1 infection: effects of highly active antiretroviral therapy provide insights into the mechanisms of naive T-cell depletion.Journal of virology · 2006Article
- Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients.The Journal of clinical investigation · 2005Article
- Cytokine profiles in human immunodeficiency virus-infected children treated with highly active antiretroviral therapy.MedGenMed : Medscape general medicine · 2005Article
- Cytokine profiles in human immunodeficiency virus-infected children treated with highly active antiretroviral therapy.Journal of the International AIDS Society · 2005Article
- Thymic function in HIV infection.Current HIV/AIDS reports · 2005Review
- Effects of exogenous IL-2 administration on the homeostasis of CD4+ T lymphocytes.Journal of clinical immunology · 2004Article
- Direct measurement of lymphocyte receptor diversity.Nucleic acids research · 2003Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Intermittent interleukin-2 (IL-2) therapy has been shown to increase the number of CD4+ T cells, preferentially cells with a naive phenotype, in patients with HIV infection. For this report we investigated the mechanism underlying this expansion by studying the relative roles of peripheral expansion and thymic output. In a cohort of six patients receiving IL-2 over a period of 1 year, the mean number of naive CD4+ T cells increased from 139 to 387 cells per microl while levels of T cell receptor rearrangement excision circles (TRECs) declined from 47,946 to 26,510 copies per 10(6) naive T cells, thus making it unlikely that the CD4+ T cell count increases were secondary to increase in thymic output. To examine directly the impact of IL-2 on peripheral expansion, peripheral blood mature, naive CD4+ T cells were labeled ex vivo with 5-bromodeoxyuridine as well as stained directly for Ki67. These studies revealed a 7-fold increase in the percentage of 5-bromodeoxyuridine-positive cells and a 20-40-fold increase in Ki67 staining in the naive CD4+ T cell pool in the setting of IL-2 administration. This degree of increase in mature CD4+ T cell turnover induced by IL-2 does not compromise the future replicative potential of these cells, because longitudinal measurements of telomere length went from 6,981 to 7,153 bp after 1 year of IL-2 therapy. These data strongly suggest that much of the increase in CD4+ cells associated with IL-2 treatment is caused by peripheral expansion of existing naive CD4+ T cells rather than increased thymic output and that these increases occur without compromising the potential of these cells for further cell division.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.