ReviewMolecular pathology : MP2002
Chaperonins in disease: mechanisms, models, and treatments.
Review in Molecular pathology : MP, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 106 citations in OpenAlex.
- The Influence of Chitosan Derivatives in Combination withPlants (Basel, Switzerland) · 2024Article
- Friends in need: How chaperonins recognize and remodel proteins that require folding assistance.Frontiers in molecular biosciences · 2022Review
- Host-Pathogen Interactions betweenMicroorganisms · 2020Article
- Circulating heat shock protein 27 as a novel marker of subclinical atherosclerosis in type 2 diabetes: a cross-sectional community-based study.BMC cardiovascular disorders · 2020Article
- Antibodies to Heat Shock Proteins 90α and 90β in Psoriasis.Archivum immunologiae et therapiae experimentalis · 2020Article
- RapidAIM: a culture- and metaproteomics-based Rapid Assay of Individual Microbiome responses to drugs.Microbiome · 2020Article
- Molecular characteristics of a novel HSP60 gene and its differential expression in Manila clams (Ruditapes philippinarum) under thermal and hypotonic stress.Cell stress & chaperones · 2018Article
- Expression of Heat Shock Protein 27 in Benign Prostatic Hyperplasia with Chronic Inflammation.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Proteomics profiling of chikungunya-infected Aedes albopictus C6/36 cells reveal important mosquito cell factors in virus replication.PLoS neglected tropical diseases · 2015Article
- Neonatal Death and Heart Failure in Mouse with Transgenic HSP60 Expression.BioMed research international · 2015Article
- A novel insecticidal GroEL protein from Xenorhabdus nematophila confers insect resistance in tobacco.Transgenic research · 2014Article
- Sequencing and de novo assembly of the western tarnished plant bug (Lygus hesperus) transcriptome.PloS one · 2013Article
- Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis.PloS one · 2013Article
- An insecticidal protein from Xenorhabdus ehlersii triggers prophenoloxidase activation and hemocyte decrease in Galleria mellonella.Current microbiology · 2012Article
- Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome.Prostate cancer and prostatic diseases · 2010Article
- Listeria monocytogenes uses Listeria adhesion protein (LAP) to promote bacterial transepithelial translocation and induces expression of LAP receptor Hsp60.Infection and immunity · 2010Article
- GroEL and lipopolysaccharide from Francisella tularensis live vaccine strain synergistically activate human macrophages.Infection and immunity · 2010Article
- The francisella tularensis proteome and its recognition by antibodies.Frontiers in microbiology · 2010Article
- The innate immune and systemic response in honey bees to a bacterial pathogen, Paenibacillus larvae.BMC genomics · 2009Article
- Candidate autoantigens identified by mass spectrometry in early rheumatoid arthritis are chaperones and citrullinated glycolytic enzymes.Arthritis research & therapy · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chaperonins are oligomeric proteins that assist in the folding of nascent or denatured proteins. Bacterial chaperonins are strongly immunogenic and can cause tissue pathology. They have been implicated in infection, autoimmune disease, and idiopathic or multifactorial diseases, such as arthritis and atherosclerosis. Chaperonin 60 proteins are also involved in prion diseases. In the past few years, much progress has been made in unravelling the involvement of various bacterial and mammalian chaperonin 60 (Cpn 60 or hsp 60) proteins in such diseases, and in proposing mechanisms for their biological actions, although we are still some way from a full understanding of chaperonin action that might lead to immunotherapeutic approaches. This review focuses on the current knowledge of the roles of Cpn 60 in the pathology of infectious and immune diseases, and discusses models for the actions of this molecule. Some potential therapeutic strategies will also be reviewed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.