ArticleThe EMBO journal2002
Mos is not required for the initiation of meiotic maturation in Xenopus oocytes.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 107 citations in OpenAlex.
- Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics.eLife · 2025Article
- The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division.Nature communications · 2021Article
- Translational Control ofCells · 2020Review
- Review
- Effects of Ferrocenyl 4-(Imino)-1,4-Dihydro-quinolines onInternational journal of molecular sciences · 2020Article
- Hydrogen Sulfide Impairs Meiosis Resumption inCells · 2020Article
- The G2-to-M transition from a phosphatase perspective: a new vision of the meiotic division.Cell division · 2020Review
- MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Review
- Maintained MPF Level after Oocyte Vitrification Improves Embryonic Development after IVF, but not after Somatic Cell Nuclear Transfer.Molecules and cells · 2017Article
- Vertebrate Reproduction.Cold Spring Harbor perspectives in biology · 2015Review
- Phosphorylation of ARPP19 by protein kinase A prevents meiosis resumption in Xenopus oocytes.Nature communications · 2014Article
- Zar1 represses translation in Xenopus oocytes and binds to the TCS in maternal mRNAs with different characteristics than Zar2.Biochimica et biophysica acta · 2013Article
- The phosphorylation of ARPP19 by Greatwall renders the auto-amplification of MPF independently of PKA in Xenopus oocytes.Journal of cell science · 2013Article
- Control of oocyte growth and meiotic maturation in Caenorhabditis elegans.Advances in experimental medicine and biology · 2013Review
- A dynamical model of oocyte maturation unveils precisely orchestrated meiotic decisions.PLoS computational biology · 2012Article
- Signal propagation of the MAPK cascade in Xenopus oocytes: role of bistability and ultrasensitivity for a mixed problem.Journal of mathematical biology · 2012Article
- Unfertilized Xenopus eggs die by Bad-dependent apoptosis under the control of Cdk1 and JNK.PloS one · 2011Article
- Mos in the oocyte: how to use MAPK independently of growth factors and transcription to control meiotic divisions.Journal of signal transduction · 2011Article
- Developmental timing of mRNA translation--integration of distinct regulatory elements.Molecular reproduction and development · 2010Review
- MSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling.Developmental biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Xenopus oocytes, the c-mos proto-oncogene product has been proposed to act downstream of progesterone to control the entry into meiosis I, the transition from meiosis I to meiosis II, which is characterized by the absence of S phase, and the metaphase II arrest seen prior to fertilization. Here, we report that inhibition of Mos synthesis by morpholino antisense oligonucleotides does not prevent the progesterone-induced initiation of Xenopus oocyte meiotic maturation, as previously thought. Mos-depleted oocytes complete meiosis I but fail to arrest at metaphase II, entering a series of embryonic-like cell cycles accompanied by oscillations of Cdc2 activity and DNA replication. We propose that the unique and conserved role of Mos is to prevent mitotic cell cycles of the female gamete until the fertilization in Xenopus, starfish and mouse oocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.