ArticleProtein science : a publication of the Protein Society2002
Sequence conservation in the chagasin family suggests a common trend in cysteine proteinase binding by unrelated protein inhibitors.
Article in Protein science : a publication of the Protein Society, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 58 citations in OpenAlex.
- Microbial inhibitors of cysteine proteases.Medical microbiology and immunology · 2016Review
- Article
- Inhibitor of cysteine proteases is critical for motility and infectivity of Plasmodium sporozoites.mBio · 2013Article
- Cysteine protease inhibitor (AcStefin) is required for complete cyst formation of Acanthamoeba.Eukaryotic cell · 2013Article
- Phylogenetic analysis of the human thyroglobulin regions.Thyroid research · 2012Article
- Solution structure of a phytocystatin from Ananas comosus and its molecular interaction with papain.PloS one · 2012Article
- The macromolecular complex of ICP and falcipain-2 from Plasmodium: preparation, crystallization and preliminary X-ray diffraction analysis.Acta crystallographica. Section F, Structural biology and crystallization communications · 2011Article
- Prokaryote-derived protein inhibitors of peptidases: A sketchy occurrence and mostly unknown function.Biochimie · 2010Review
- Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes.PLoS pathogens · 2010Article
- Phylogenomic analysis of the cystatin superfamily in eukaryotes and prokaryotes.BMC evolutionary biology · 2009Article
- The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin.Molecular and biochemical parasitology · 2009Article
- Influence of parasite encoded inhibitors of serine peptidases in early infection of macrophages with Leishmania major.Cellular microbiology · 2009Article
- The role of conserved residues of chagasin in the inhibition of cysteine peptidases.FEBS letters · 2008Article
- Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence.Molecular microbiology · 2007Article
- Protein turnover and differentiation in Leishmania.International journal for parasitology · 2007Review
- The second cysteine protease inhibitor, EhICP2, has a different localization in trophozoites of Entamoeba histolytica than EhICP1.Parasitology research · 2006Article
- Role of chagasin-like inhibitors as endogenous regulators of cysteine proteases in parasitic protozoa.Parasitology research · 2006Review
- The structure of Leishmania mexicana ICP provides evidence for convergent evolution of cysteine peptidase inhibitors.The Journal of biological chemistry · 2006Article
- Inhibition of mammalian cathepsins by Plesiomonas shigelloides.Folia microbiologica · 2006Article
- Expressed sequence tags from the oomycete fish pathogen Saprolegnia parasitica reveal putative virulence factors.BMC microbiology · 2005Article
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recently described inhibitor of cysteine proteinases from Trypanosoma cruzi, chagasin, was found to have close homologs in several eukaryotes, bacteria and archaea, the first protein inhibitors of cysteine proteases in prokaryotes. These previously uncharacterized 110-130 residue-long proteins share a well-conserved sequence motif that corresponds to two adjacent beta-strands and the short loop connecting them. Chagasin-like proteins also have other conserved, mostly aromatic, residues, and share the same predicted secondary structure. These proteins adopt an all-beta fold with eight predicted beta-strands of the immunoglobulin type. The phylogenetic distribution of the chagasins generally correlates with the presence of papain-like cysteine proteases. Previous studies have uncovered similar trends in cysteine proteinase binding by two unrelated inhibitors, stefin and p41, that belong to the cystatin and thyroglobulin families, respectively. A hypothetical model of chagasin-cruzipain interaction suggests that chagasin may dock to the cruzipain active site in a similar manner with the conserved NPTTG motif of chagasin forming a loop that is similar to the wedge structures formed at the active sites of papain and cathepsin L by stefin and p41.
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