ArticleProtein science : a publication of the Protein Society2002
Crucial stages of protein folding through a solvable model: predicting target sites for enzyme-inhibiting drugs.
Article in Protein science : a publication of the Protein Society, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- Rationale for more diverse inhibitors in competition with substrates in HIV-1 protease.Biophysical journal · 2010Article
- Temperature dependence of fluctuations in HIV1-protease.European biophysics journal : EBJ · 2010Article
- Analyzing pathogenic mutations of C5 domain from cardiac myosin binding protein C through MD simulations.European biophysics journal : EBJ · 2008Article
- Stability and kinetic properties of C5-domain from myosin binding protein C and its mutants.Biophysical journal · 2008Article
- Testing simplified proteins models of the hPin1 WW domain.Biophysical journal · 2006Article
- Protein flexibility prediction by an all-atom mean-field statistical theory.Protein science : a publication of the Protein Society · 2005Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An exactly solvable model based on the topology of a protein native state is applied to identify bottlenecks and key sites for the folding of human immunodeficiency virus type 1 (HIV-1) protease. The predicted sites are found to correlate well with clinical data on resistance to Food and Drug Administration-approved drugs. It has been observed that the effects of drug therapy are to induce multiple mutations on the protease. The sites where such mutations occur correlate well with those involved in folding bottlenecks identified through the deterministic procedure proposed in this study. The high statistical significance of the observed correlations suggests that the approach may be promisingly used in conjunction with traditional techniques to identify candidate locations for drug attacks.
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