ArticleGenes and immunity2002
CD40L association with protection from severe malaria.
Article in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 76 citations in OpenAlex.
- Article
- Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria.Immunity · 2024Article
- The Legacy of Infectious Disease Exposure on the Genomic Diversity of Indigenous Southern Mexicans.Genome biology and evolution · 2023Article
- The tangled web of autoreactive B cells in malaria immunity and autoimmune disease.Trends in parasitology · 2022Review
- Identifying adaptive alleles in the human genome: from selection mapping to functional validation.Human genetics · 2021Review
- Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects.BMC medical genomics · 2019Review
- Genetics of Malaria Inflammatory Responses: A Pathogenesis Perspective.Frontiers in immunology · 2019Review
- Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study.The Lancet. Haematology · 2018Article
- Review
- Malaria Host Candidate Genes Validated by Association With Current, Recent, and Historical Measures of Transmission Intensity.The Journal of infectious diseases · 2017Article
- Reappraisal of known malaria resistance loci in a large multicenter study.Nature genetics · 2014Article
- Innate sensing of malaria parasites.Nature reviews. Immunology · 2014Review
- Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution.BMC evolutionary biology · 2014Article
- Article
- The complexities of malaria disease manifestations with a focus on asymptomatic malaria.Malaria journal · 2012Review
- Article
- Investigation of host candidate malaria-associated risk/protective SNPs in a Brazilian Amazonian population.PloS one · 2012Article
- Article
- Genetic polymorphisms linked to susceptibility to malaria.Malaria journal · 2011Review
- Duality and complexity of allergic type inflammatory mechanisms in determining the outcome of malaria disease.Frontiers in immunology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD40 ligand (CD40L), a glycoprotein involved in B cell proliferation, antigen presenting cell activation, and Ig class switching, is important in the immune response to infection. Rare coding mutations in CD40L can lead to life-threatening immunodeficiency but the potential for common variants to alter disease susceptibility remains to be explored. To identify polymorphisms in CD40L, we sequenced 2.3 kb of the 5' flanking region and the first exon of the gene in DNA samples from 36 Gambian females and one chimpanzee. Diversity was lower than the average reported for other areas of the X chromosome, and only two polymorphisms were identified. The polymorphisms were genotyped in DNA samples from 957 Gambian individuals, cases and controls from a study of severe malaria. A significant reduction in risk for severe malaria (OR = 0.52, P = 0.002) was associated with males hemizygous for the CD40L-726C. Analysis by transmission disequilibrium test of 371 cases, for whom DNA from both parents was also available, confirmed the result was not due to stratification (P = 0.04). A similar but non-significant trend was found in females. This preliminary association of a common variant in CD40L with a malaria resistance phenotype encourages further genetic characterization of the role of CD40L in infectious disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.