ArticleGenes and immunity2002
A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis.
Article in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping candidate non-MHC susceptibility regions to multiple sclerosis.Genes and immunity · 2006Pooled it
- Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis.Archives of Razi Institute · 2022Article
- A non-functional galanin receptor-2 in a multiple sclerosis patient.The pharmacogenomics journal · 2019Article
- Hemoglobins as new players in multiple sclerosis: metabolic and immune aspects.Metabolic brain disease · 2016Review
- Higher minor hemoglobin A2 levels in multiple sclerosis patients correlate with lesser disease severity.Neuropsychiatric disease and treatment · 2016Article
- Investigation of IL-21 gene polymorphisms (rs2221903, rs2055979) in cases with multiple sclerosis of Azerbaijan, Northwest Iran.American journal of clinical and experimental immunology · 2015Article
- Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.Genes and immunity · 2009Article
- The genetic aspects of multiple sclerosis.Annals of Indian Academy of Neurology · 2009Article
- The complex genetics of multiple sclerosis: pitfalls and prospects.Brain : a journal of neurology · 2008Review
- A genome-wide scan in forty large pedigrees with multiple sclerosis.Journal of human genetics · 2007Article
- Follow-up investigation of 12 proposed linkage regions in multiple sclerosis.Genes and immunity · 2006Article
- Gluten: a two-edged sword. Immunopathogenesis of celiac disease.Springer seminars in immunopathology · 2005Review
- A high-density screen for linkage in multiple sclerosis.American journal of human genetics · 2005Article
- Eae19, a new locus on rat chromosome 15 regulating experimental autoimmune encephalomyelitis.Genetics · 2005Article
- A second-generation genomic screen for multiple sclerosis.American journal of human genetics · 2004Article
- Article
- Genome-wide TDT analysis in a localized population with a high prevalence of multiple sclerosis indicates the importance of a region on chromosome 14q.Genes and immunity · 2003Article
- Looking back and looking forward.Genes and immunity · 2003Article
- A genome screen for linkage in Australian sibling-pairs with multiple sclerosis.Genes and immunity · 2002Article
- Genetic analysis of multiple sclerosis.Current neurology and neuroscience reports · 2002Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136 sibling-pairs with multiple sclerosis from Denmark, Finland, Norway and Sweden by typing 399 microsatellite markers. Seventeen regions where the lod score exceeds the nominal 5% significance threshold (0.7) were identified-1q11-24, 2q24-32, 3p26.3, 3q21.1, 4q12, 6p25.3, 6p21-22, 6q21, 9q34.3, 10p15, 10p12-13, 11p15.5, 12q21.3, 16p13.3, 17q25.3, 22q12-13 and Xp22.3. Although none of these regions reaches the level of genome-wide significance, the number observed exceeds the 10 that would be expected by chance alone. Our results significantly add to the growing body of linkage data relating to multiple sclerosis.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.