ArticleNucleic acids research2002
An efficient haplotyping method with DNA pools.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- An efficient method for multi-locus molecular haplotyping.Nucleic acids research · 2007Article
- Computation of haplotypes on SNPs subsets: advantage of the "global method".BMC genetics · 2006Article
- Long-range multilocus haplotype phasing of the MHC.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Direct molecular haplotyping by melting curve analysis of hybridization probes: beta 2-adrenergic receptor haplotypes as an example.Nucleic acids research · 2005Article
- A comprehensive literature review of haplotyping software and methods for use with unrelated individuals.Human genomics · 2005Review
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Authors and funding
3 authors.
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Abstract
Determination of haplotype frequencies (the joint distribution of genetic markers) in large population samples is a powerful tool for association studies. This is due to their greater extent of polymorphism since any two bi-allelic single nucleotide polymorphisms (SNPs) generate a potential four-allele genetic marker. Therefore, a haplotype may capture a given functional polymorphism with higher statistical power than its SNP components. The statistical estimation of haplotype frequencies, usually employed in linkage disequilibrium studies, requires individual genotyping for each SNP in the haplotype, thus making it an expensive process. In this study, we describe a new method for direct measurement of haplotype frequencies in DNA pools by allele-specific, long-range haplotype amplification. The proposed method allows the efficient determination of haplotypes composed of two SNPs in close vicinity (up to 20 kb).
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