ArticleCell proliferation2002
The gene expression sequence of radiated mucosa in an animal mucositis model.
Article in Cell proliferation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 76 citations in OpenAlex.
- A phase III randomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositis in patients undergoing hematopoietic cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2007Trial
- Stereotactic body radiotherapy as a rescue modality for definitive treatment of therapy-refractory fistulas after pancreatic surgery.Langenbeck's archives of surgery · 2026Article
- Pathogenesis and Amelioration of Radiation-Induced Oral Mucositis.Current treatment options in oncology · 2022Review
- Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma.PloS one · 2018Article
- Article
- Assessment of the effect of local application of amifostine on acute radiation-induced oral mucositis in guinea pigs.Journal of radiation research · 2014Article
- Local and systemic pathogenesis and consequences of regimen-induced inflammatory responses in patients with head and neck cancer receiving chemoradiation.Mediators of inflammation · 2014Article
- Emerging evidence on the pathobiology of mucositis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Review
- Emerging evidence on the pathobiology of mucositis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Review
- Alteration of the redox state with reactive oxygen species for 5-fluorouracil-induced oral mucositis in hamsters.PloS one · 2013Article
- Serum amyloid P ameliorates radiation-induced oral mucositis and fibrosis.Fibrogenesis & tissue repair · 2010Article
- New pathways for alimentary mucositis.Journal of oncology · 2008Article
- Gene expression arrays as a tool to unravel mechanisms of normal tissue radiation injury and prediction of response.World journal of gastroenterology · 2007Review
- Current practice and knowledge of oral care for cancer patients: a survey of supportive health care providers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2005Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral mucositis is a common, dose-limiting, acute toxicity of radiation therapy administered for the treatment of cancers of the head and neck. Accumulating data would suggest that the pathogenesis of mucositis is complex and involves the sequential interaction of all cell types of the oral mucosa, as well as a number of cytokines and elements of the oral environment. While a number of studies have reported on gene expression of particular cell types in response to radiation, the overall response of irradiated mucosa has only been evaluated in a limited way. The present study was undertaken to evaluate the expression of a target group of genes using RNA quantification assays and, more broadly, to assess patterns of mucosal gene expression using DNA microarray hybridization. Our results demonstrate the sequential upregulation of a series of genes that, when taken collectively, suggest an intricate functional interaction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.