Evidence map›Paper›PMID 12137661›Full record

SynthesisThe Cochrane database of systematic reviews2002

Nitric oxide donors for the treatment of preterm labour.

K Duckitt, S Thornton

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The Cochrane database of systematic reviews, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 10 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Combination of tocolytic agents for inhibiting preterm labour.The Cochrane database of systematic reviews · 2014
    Pooled it
  3. Oxytocin receptor antagonists for inhibiting preterm labour.The Cochrane database of systematic reviews · 2014
    Pooled it
  4. Calcium channel blockers for inhibiting preterm labour and birth.The Cochrane database of systematic reviews · 2014
    Pooled it
  5. Nitric oxide donors for treating preterm labour.The Cochrane database of systematic reviews · 2014
    Pooled it
  6. Betamimetics for inhibiting preterm labour.The Cochrane database of systematic reviews · 2014
    Pooled it
  7. Progestational agents for treating threatened or established preterm labour.The Cochrane database of systematic reviews · 2014
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Comparison between nitroglycerin dermal patch and nifedipine for treatment of preterm labor: a randomized clinical trial.Journal of perinatology : official journal of the California Perinatal Association · 2014
    Trial
  12. Observational
  13. Maternal plasma nitric oxide metabolites and cervical length assessment in predicting the tocolytic therapy in preterm labor in Isfahan.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016
    Article
  14. Article
  15. Short-term tocolytics for preterm delivery - current perspectives.International journal of women's health · 2014
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

K DuckittNuffield Department of Obstetrics and Gynaecology, Level 3, Women's Centre, John Radcliffe Hospital, Headington, Oxford, UK, OX3 9DU. kirsten.duckitt@obstetrics-gynaecology.oxford.ac.uk
S Thornton
John Radcliffe Hospital · GBPeninsula College of Medicine and Dentistry · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA number of tocolytics have been advocated for the treatment of threatened preterm labour in order to delay delivery. The rationale is that a delay in delivery may be associated with improved neonatal morbidity or mortality. Nitric oxide donors, such as nitroglycerin, have been used to relax the uterus. This review addresses their efficacy, side effects and influence on neonatal outcome.

objectivesTo determine whether nitric oxide donors administered in threatened preterm labour are associated with a delay in delivery, adverse side effects or improved neonatal outcome. SEARCH STRATEGY: A comprehensive search of the Cochrane Pregnancy and Childbirth Group trials register (March 2002) and the Cochrane Controlled Trials Register (The Cochrane Library, Issue 1, 2002) was undertaken. SELECTION CRITERIA: Randomised controlled trials of nitric oxide donors administered for tocolysis. DATA COLLECTION AND ANALYSIS: Trial quality assessment and data extraction were done independently by two reviewers. MAIN

resultsFive randomised controlled trials (466 women) were included. Nitroglycerine was the NO donor used in all these trials. Nitric oxide donors did not delay delivery nor improve neonatal outcome when compared with placebo, no treatment or alternative tocolytics such as ritodrine, albuterol and magnesium sulphate. There was, however, a reduction in number of deliveries less than 37 weeks when compared with alternative tocolytics but the numbers of deliveries before 32 and 34 weeks were not influenced. Side effects (other than headache) were reduced in women who received nitric oxide donors rather than other tocolytics. However, women were significantly more likely to experience headache when NO donors had been used. REVIEWER'S

conclusionsThere is currently insufficient evidence to support the routine administration of nitric oxide donors in the treatment of threatened preterm labour.

Indexed as

FemaleHumansNitric Oxide DonorsNitroglycerinObstetric Labor, PrematurePregnancyRandomized Controlled Trials as TopicTocolysisTocolytic AgentsNitric Oxide DonorsNitroglycerinTocolytic Agents

Identifiers

PMID12137661
OpenAlexW1932202182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.