Trial reportMediators of inflammation2002
Effects after inhalation of (1-->3)-beta-D-glucan and relation to mould exposure in the home.
Trial report in Mediators of inflammation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 51 citations in OpenAlex.
- Differential effects of exposure to toxic or nontoxic mold spores on brain inflammation and Morris water maze performance.Behavioural brain research · 2023Article
- Cytotoxic and Inflammatory Potential of Air Samples from Occupational Settings with Exposure to Organic Dust.Toxics · 2017Article
- Inhalable dust, endotoxins and (1-3)-β-d-glucans as indicators of exposure in waste sorting plant environment.Aerobiologia · 2017Article
- Review
- Fungal pollution of indoor environments and its management.Saudi journal of biological sciences · 2012Article
- Relationship between sick building syndrome and indoor environmental factors in newly built Japanese dwellings.International archives of occupational and environmental health · 2009Article
- Fungal Fragments in Moldy Houses: A Field Study in Homes in New Orleans and Southern Ohio.Atmospheric environment (Oxford, England : 1994) · 2007Article
- Meeting Abstracts. Recent Developments in 1,3-beta-Glucan Biology: Proceedings of the 5th Glucan Symposium Tokyo, December 8, 2006.Mediators of inflammation · 2007Article
- Fungal levels in the home and allergic rhinitis by 5 years of age.Environmental health perspectives · 2005Article
- Domestic exposure to fungi and total serum IgE levels in asthmatic children.Mediators of inflammation · 2005Article
- Comparison of biocontaminant levels associated with hard vs. carpet floors in nonproblem schools: results of a year long study.Journal of exposure analysis and environmental epidemiology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDamp conditions indoors favour the growth of microorganisms, and these contain several agents that may cause inflammation when inhaled. Moulds contain a polyglucose in their cell wall, defined as (1-->3)-beta-D-glucan, exhibiting effects on inflammatory cells.
aimThe aim of the present study was to evaluate whether an inhalation challenge to purified (1-->3)-beta-D-glucan (grifolan) in humans could induce effects on inflammatory markers in blood, and to evaluate whether the reactions were related to the home exposure to (1-->3)-beta-D-glucan.
methodsSeventeen subjects in homes with high levels of airborne (1-->3)-beta-D-glucan (G-high) and 18 subjects in homes with low levels of (1-->3)-beta-D-glucan (G-low) underwent two randomised, double-blind inhalation challenges, one to (1-->3)-beta-D-glucan suspended in saline and one to saline alone. A blood sample was taken before and after the challenges, and differential cell count, granulocyte enzymes in serum and the secretion of cytokines from peripheral blood mononuclear cells (PBMC) were measured.
resultsInhalation challenge with (1-->3)-beta-D-glucan induced a decrease in the secretion of tumour necrosis factor alpha from endotoxin-stimulated PBMC in the G-high group as well as in the G-low group. In the G-high group, the inhalation of (1-->3)-beta-D-glucan induced an increase in blood lymphocytes that was significantly different from the saline-induced effect.
conclusionsThe results suggest that an inhalation challenge to (1-->3)-beta-D-glucan has an effect on inflammatory cells and this effect may be related to a chronic exposure to moulds at home.
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