ArticleNucleic acids research2002
Selective stimulation of translational expression by Alu RNA.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 72 citations in OpenAlex.
- Reading the SINEs - functionality in noncoding RNA 'cheap genes'.RNA biology · 2026Review
- Functional analysis of RNA motifs essential for BC200 RNA-mediated translational regulation.BMB reports · 2020Article
- Z-DNA and Z-RNA in human disease.Communications biology · 2019Review
- Retrotransposons as regulators of gene expression.Science (New York, N.Y.) · 2016Review
- Direct binding of the Alu binding protein dimer SRP9/14 to 40S ribosomal subunits promotes stress granule formation and is regulated by Alu RNA.Nucleic acids research · 2014Article
- Reporters transiently transfected into mammalian cells are highly sensitive to translational repression induced by dsRNA expression.PloS one · 2014Article
- Alu- and 7SL RNA Analogues Suppress MCF-7 Cell Viability through Modulating the Transcription of Endoplasmic Reticulum Stress Response Genes.Acta naturae · 2013Article
- A gene expression restriction network mediated by sense and antisense Alu sequences located on protein-coding messenger RNAs.BMC genomics · 2013Article
- The sequence and analysis of a Chinese pig genome.GigaScience · 2012Article
- Inverted Alu dsRNA structures do not affect localization but can alter translation efficiency of human mRNAs independent of RNA editing.Nucleic acids research · 2012Article
- SINE RNA induces severe developmental defects in Arabidopsis thaliana and interacts with HYL1 (DRB1), a key member of the DCL1 complex.PLoS genetics · 2008Article
- The take and give between retrotransposable elements and their hosts.Annual review of genetics · 2008Review
- PCR-based detection of Pol III-transcribed transposons and its application to the rodent model of ultraviolet response.Cell stress & chaperones · 2008Article
- Article
- Alu RNP and Alu RNA regulate translation initiation in vitro.Nucleic acids research · 2006Article
- Alu elements as regulators of gene expression.Nucleic acids research · 2006Review
- Short interspersed elements (SINEs) are a major source of canine genomic diversity.Genome research · 2005Article
- Transcribed Tc1-like transposons in salmonid fish.BMC genomics · 2005Article
- The double-stranded-RNA-binding motif: interference and much more.Nature reviews. Molecular cell biology · 2004Review
- Patterns of insertions and their covariation with substitutions in the rat, mouse, and human genomes.Genome research · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Human Alu and adenovirus VA1 RNAs each stimulate the translational expression of reporter genes in co-transient transfection assays without affecting either the rate of global protein synthesis or the abundance of the reporter mRNA. This selective, post-transcriptional stimulation of expression, which is observed in human and mouse cell lines and for three reporters, acts through a PKR- independent mechanism. The activity of Alu and VA1 RNAs in this assay is transient, causing a reduction in the lag time for the translational expression of the newly synthesized reporter mRNAs. The reduction in this lag time accounts for the relative selectivity of the effect upon the expression of the reporter and suggests novel roles for Alu and VA1 RNA in cell stress recovery and viral infection. Deletion analysis demonstrates that a specific region residing within the right monomer of the dimeric Alu consensus sequence is necessary for activity. Highly abundant left Alu monomer transcripts are inactive but the right Alu monomer is fully active, although its transcripts are scarce. Mouse B1 and B2 SINE RNAs stimulate reporter gene expression in mouse cells, suggesting that this activity is a general property of eucaryotic SINEs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.