ArticleGenetics2002
Isolation of Su(var)3-7 mutations by homologous recombination in Drosophila melanogaster.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Article
- Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila.Cold Spring Harbor perspectives in biology · 2013Review
- JIL-1 and Su(var)3-7 interact genetically and counteract each other's effect on position-effect variegation in Drosophila.Genetics · 2010Article
- Sumoylation of Drosophila SU(VAR)3-7 is required for its heterochromatic function.Nucleic acids research · 2010Article
- SU(VAR)3-7 links heterochromatin and dosage compensation in Drosophila.PLoS genetics · 2008Article
- Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation.PLoS genetics · 2007Article
- Conserved domains control heterochromatin localization and silencing properties of SU(VAR)3-7.Chromosoma · 2006Article
- Article
- Article
- Mutations in Su(var)205 and Su(var)3-7 suppress P-element-dependent silencing in Drosophila melanogaster.Genetics · 2004Article
- An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster.Genome research · 2004Article
- Genetic analysis of the ADGF multigene family by homologous recombination and gene conversion in Drosophila.Genetics · 2003Article
- Ends-out, or replacement, gene targeting in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Knockout targeting of the Drosophila nap1 gene and examination of DNA repair tracts in the recombination products.Genetics · 2003Article
- Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis.The EMBO journal · 2003Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Su(var)3-7 gene, a haplo-suppressor and triplo-enhancer of position-effect variegation (PEV), encodes a zinc finger heterochromatin-associated protein. To understand the role of this protein in heterochromatin and genomic silencing, mutations were generated by homologous recombination. The donor fragment contained a yellow(+) gene and 7.6 kb of the Su(var)3-7 gene inserted between two FRTs. The Su(var)3-7 sequence contained three stop codons flanking an I-SceI cut site located in the 5' half of the gene. Using two different screening approaches, we obtained an allelic series composed of three mutant alleles. The three mutations are dominant suppressors of PEV. One behaves as a null mutation and results in a maternal-effect recessive lethal phenotype that can be rescued by a zygotic paternal wild-type gene. A P transposon zygotically expressing a Su(var)3-7 full-length cDNA also rescues the mutant phenotype. One hypomorphic allele is viable and the pleiotropic phenotype showed by adult flies indicates that rapidly and late dividing cells seem the most affected by reduced amounts of Su(var)3-7 protein. All three mutants were characterized at the molecular level. Each expresses a portion of the Su(var)3-7 protein that is unable to enter the nucleus and bind chromatin.
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