ArticleGenetics2002
Identification of six loci in which mutations partially restore peroxisome biogenesis and/or alleviate the metabolic defect of pex2 mutants in podospora.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Establishment of the monomeric yellow-green fluorescent protein mNeonGreen for life cell imaging in mycelial fungi.AMB Express · 2020Article
- Dynamic Regulation of Peroxisomes and Mitochondria during Fungal Development.Journal of fungi (Basel, Switzerland) · 2020Review
- Distinct Contributions of the Peroxisome-Mitochondria Fission Machinery During Sexual Development of the FungusFrontiers in microbiology · 2020Article
- Wood utilization is dependent on catalase activities in the filamentous fungus Podospora anserina.PloS one · 2012Article
- Contributions of the peroxisome and β-oxidation cycle to biotin synthesis in fungi.The Journal of biological chemistry · 2011Article
- A novel family of dehydrin-like proteins is involved in stress response in the human fungal pathogen Aspergillus fumigatus.Molecular biology of the cell · 2011Article
- Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans.Genetics · 2008Article
- The WW domain protein PRO40 is required for fungal fertility and associates with Woronin bodies.Eukaryotic cell · 2007Article
- Regulatory genes controlling fatty acid catabolism and peroxisomal functions in the filamentous fungus Aspergillus nidulans.Eukaryotic cell · 2006Article
- Lack of mitochondrial citrate synthase discloses a new meiotic checkpoint in a strict aerobe.The EMBO journal · 2002Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peroxins (PEX) are proteins required for peroxisome biogenesis. Mutations in PEX genes cause lethal diseases in humans, metabolic defects in yeasts, and developmental disfunctions in plants and filamentous fungi. Here we describe the first large-scale screening for suppressors of a pex mutation. In Podospora anserina, pex2 mutants exhibit a metabolic defect [inability to grow on medium containing oleic acid (OA medium) as sole carbon source] and a developmental defect (inability to differentiate asci in homozygous crosses). Sixty-three mutations able to restore growth of pex2 mutants on OA medium have been analyzed. They fall in six loci (suo1 to suo6) and act as dominant, allele-nonspecific suppressors. Most suo mutations have pleiotropic effects in a pex2(+) background: formation of unripe ascospores (all loci except suo5 and suo6), impaired growth on OA medium (all loci except suo4 and suo6), or sexual defects (suo4). Using immunofluorescence and GFP staining, we show that peroxisome biogenesis is partially restored along with a low level of ascus differentiation in pex2 mutant strains carrying either the suo5 or the suo6 mutations. The data are discussed with respect to beta-oxidation of fatty acids, peroxisome biogenesis, and cell differentiation.
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