Evidence map›Paper›PMID 12135984›Full record

ArticleThe Journal of cell biology2002

Transcriptome profiling to identify genes involved in peroxisome assembly and function.

Jennifer J Smith, Marcello Marelli, Rowan H Christmas, Franco J Vizeacoumar, David J Dilworth, Trey Ideker, Timothy Galitski, Krassen Dimitrov, Richard A Rachubinski, John D Aitchison

Abstract read
In one paragraph

Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed.

  1. Article
  2. Review
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  7. Article
  8. Review
  9. Article
  10. Anaerobic peroxisomes inProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Article
  12. Pex35 is a regulator of peroxisome abundance.Journal of cell science · 2017
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer J SmithThe Institute for Systems Biology, 1441 N. 34th Street, Seattle, WA 98103-8904, USA.
Marcello Marelli
Rowan H Christmas
Franco J Vizeacoumar
David J Dilworth
Trey Ideker
Timothy Galitski
Krassen Dimitrov
Richard A Rachubinski
John D Aitchison

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yeast cells were induced to proliferate peroxisomes, and microarray transcriptional profiling was used to identify PEX genes encoding peroxins involved in peroxisome assembly and genes involved in peroxisome function. Clustering algorithms identified 224 genes with expression profiles similar to those of genes encoding peroxisomal proteins and genes involved in peroxisome biogenesis. Several previously uncharacterized genes were identified, two of which, YPL112c and YOR084w, encode proteins of the peroxisomal membrane and matrix, respectively. Ypl112p, renamed Pex25p, is a novel peroxin required for the regulation of peroxisome size and maintenance. These studies demonstrate the utility of comparative gene profiling as an alternative to functional assays to identify genes with roles in peroxisome biogenesis.

Indexed as

Gene Expression Regulation, FungalGenes, FungalGene Expression ProfilingPeroxisomesSaccharomyces cerevisiaeTranscriptional Activation

Identifiers

PMID12135984
PMCPMC2173120

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.