ArticlePharmaceutical research2002
Comparison of oral absorption and bioavailablity of drugs between monkey and human.
Article in Pharmaceutical research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacological Effect of Orally Administered CORT125134: An Adaptive, Double-Blind, Randomized, Placebo-Controlled Phase 1 Clinical Study.Clinical pharmacology in drug development · 2018Trial
- Review
- Oral drug absorption in pediatrics: the intestinal wall, its developmental changes and current tools for predictions.Biopharmaceutics & drug disposition · 2017Review
- Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models.Clinical pharmacokinetics · 2016Review
- Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination.The AAPS journal · 2016Review
- Animal versus human oral drug bioavailability: do they correlate?European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2014Article
- The use of ROC analysis for the qualitative prediction of human oral bioavailability from animal data.Pharmaceutical research · 2014Article
- Impact of excipient interactions on drug bioavailability from solid dosage forms.Pharmaceutical research · 2012Review
- Species difference in intestinal absorption mechanism of etoposide and digoxin between cynomolgus monkey and rat.Pharmaceutical research · 2008Article
- The role of permeability in drug ADME/PK, interactions and toxicity--presentation of a permeability-based classification system (PCS) for prediction of ADME/PK in humans.Pharmaceutical research · 2008Article
- Gastric pH and gastric residence time in fasted and fed conscious cynomolgus monkeys using the Bravo pH system.Pharmaceutical research · 2008Article
- Towards quantitative prediction of oral drug absorption.Clinical pharmacokinetics · 2008Review
- Development and validation of a physiology-based model for the prediction of oral absorption in monkeys.Pharmaceutical research · 2007Article
- Lead Optimization in Discovery Drug Metabolism and Pharmacokinetics/Case study: The Hepatitis C Virus (HCV) Protease Inhibitor SCH 503034.Perspectives in medicinal chemistry · 2007Article
- Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.Pharmaceutical research · 2006Review
- Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1.Pharmaceutical research · 2006Article
- Exploratory population pharmacokinetics (e-PPK) analysis for predicting human PK using exploratory ADME data during early drug discovery research.European journal of drug metabolism and pharmacokineticsArticle
- Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?European journal of drug metabolism and pharmacokineticsArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the oral absorption and bioavailability of numerous drugs with a wide variety of physicochemical and pharmacological properties between humans and monkeys and to explore potential reasons for the findings.
methodsData for fraction of dose absorbed (Fa) and oral absolute bioavailability (F) were obtained by an extensive Medline database search. Inclusion and exclusion criteria were the same as those reported in our previous studies. A total of 43 and 35 drugs were selected for Fa and F comparison, respectively. The time to reach peak concentration (t(max)), total clearance, and nonrenal clearance were evaluated for 15, 28, and 13 drugs, respectively.
resultsFa values in monkeys were similar or identical to those in humans. Additionally, similar t(max) values were seen in monkeys and humans at comparable doses, thus indicating comparable absorption kinetics between the two species. Conversely, F values in monkeys were generally lower with coumarin being a marked exception. Both total and nonrenal clearances were evaluated and found to be generally greater in monkeys, supporting a generally higher first-pass metabolism and lower F in this species. This was also supported by published data suggesting greater in vitro hepatic drug metabolism for monkeys as compared to humans.
conclusionsMonkeys appear to be a good predictor of Fa in humans. However, a generally lower F makes monkeys a potentially poor predictor of human F. Higher reported metabolic clearances and hepatic enzyme activities in monkeys may account for this observation.
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Registered trials
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