ArticleMolecular biology of the cell2002
Role for YakA, cAMP, and protein kinase A in regulation of stress responses of Dictyostelium discoideum cells.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling inCells · 2025Review
- Simulated Heat Waves Affect Cell Fate and Fitness in the Social Amoeba Dictyostelium discoideum.Microbial ecology · 2025Article
- MaPom1, a Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase, Positively Regulates Thermal and UV-B Tolerance inInternational journal of molecular sciences · 2024Article
- The aerotaxis ofFrontiers in cell and developmental biology · 2023Article
- Minibrain-related kinase/dual-specificity tyrosine-regulated kinase 1B implication in stem/cancer stem cells biology.World journal of stem cells · 2020Review
- Curcumin affects gene expression and reactive oxygen species via a PKA dependent mechanism in Dictyostelium discoideum.PloS one · 2017Article
- Transcriptional analysis of Volvox photoreceptors suggests the existence of different cell-type specific light-signaling pathways.Current genetics · 2015Article
- Review
- Bio-electrospraying and aerodynamically assisted bio-jetting the model eukaryotic Dictyostelium discoideum: assessing stress and developmental competency post treatment.Journal of the Royal Society, Interface · 2011Article
- DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.Genes & development · 2011Article
- Roles of the DYRK kinase Pom2 in cytokinesis, mitochondrial morphology, and sporulation in fission yeast.PloS one · 2011Article
- KeaA, a Dictyostelium Kelch-domain protein that regulates the response to stress and development.BMC developmental biology · 2010Article
- DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.The Journal of biological chemistry · 2008Article
- A secreted factor represses cell proliferation in Dictyostelium.Development (Cambridge, England) · 2005Article
- Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts.The Journal of biological chemistry · 2005Article
- cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection.Journal of muscle research and cell motility · 2002Review
- A user's guide to restriction enzyme-mediated integration in Dictyostelium.Journal of muscle research and cell motility · 2002Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The Dictyostelium protein kinase YakA is required for the growth-to-development transition. During growth YakA controls the cell cycle, regulating the intervals between cell divisions. When starved for nutrients Dictyostelium cells arrest growth and undergo changes in gene expression, decreasing vegetative mRNAs and inducing the expression of pkaC. YakA is an effector of these changes, being necessary for the decrease of vegetative mRNA expression and the increase of protein kinase A (PKA) activity that will ultimately regulate expression of adenylyl cyclase, cAMP synthesis, and the induction of development. We report a role for this kinase in the response to nitrosoative or oxidative stress of Dictyostelium cells. Hydrogen peroxide and sodium nitroprusside arrest the growth of cells and trigger cAMP synthesis and activation of PKA in a manner similar to the well-established response to nutrient starvation. We have found that yakA null cells are hypersensitive to nitrosoative/oxidative stress and that a second-site mutation in pkaC suppresses this sensitivity. The response to different stresses has been investigated and YakA, cAMP, and PKA have been identified as components of the pathway that regulate the growth arrest that follows treatment with compounds that generate reactive oxygen species. The effect of different types of stress was evaluated in Dictyostelium and the YakA/PKA pathway was also implicated in the response to heat stress.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.