ArticleJournal of virology2002
Heparan sulfate mediates infection of high-neurovirulence Theiler's viruses.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Electrostatic interactions at the five-fold axis alter heparin-binding phenotype and drive enterovirus A71 virulence in mice.PLoS pathogens · 2019Article
- Enhancing the Tumor Selectivity of a Picornavirus Virotherapy Promotes Tumor Regression and the Accumulation of Infiltrating CD8+ T Cells.Molecular cancer therapeutics · 2016Article
- Role of Heparan Sulfate in Cellular Infection of Integrin-Binding Coxsackievirus A9 and Human Parechovirus 1 Isolates.PloS one · 2016Article
- Enterovirus 71 uses cell surface heparan sulfate glycosaminoglycan as an attachment receptor.Journal of virology · 2013Article
- Symmetry-related clustering of positive charges is a common mechanism for heparan sulfate binding in enteroviruses.Journal of virology · 2012Article
- A mouse-passaged dengue virus strain with reduced affinity for heparan sulfate causes severe disease in mice by establishing increased systemic viral loads.Journal of virology · 2008Article
- Human rhinovirus type 54 infection via heparan sulfate is less efficient and strictly dependent on low endosomal pH.Journal of virology · 2007Article
- N- and 6-O-sulfated heparan sulfates mediate internalization of coxsackievirus B3 variant PD into CHO-K1 cells.Journal of virology · 2006Article
- Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated.Virology · 2006Article
- Persistent infection of RAW264.7 macrophages with the DA strain of Theiler's murine encephalomyelitis virus: An in vitro model to study viral persistence.Journal of neurovirology · 2006Article
- Differential usage of carbohydrate co-receptors influences cellular tropism of Theiler's murine encephalomyelitis virus infection of the central nervous system.Glycoconjugate journal · 2006Review
- L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Capsid region involved in hepatitis A virus binding to glycophorin A of the erythrocyte membrane.Journal of virology · 2004Article
- Heparan sulfate-independent infection attenuates high-neurovirulence GDVII virus-induced encephalitis.Journal of virology · 2004Article
- Virus persistence in an animal model of multiple sclerosis requires virion attachment to sialic acid coreceptors.Journal of virology · 2004Article
- Differential distribution of the JC virus receptor-type sialic acid in normal human tissues.The American journal of pathology · 2004Article
- Heparan sulfates and coxsackievirus-adenovirus receptor: each one mediates coxsackievirus B3 PD infection.Journal of virology · 2003Article
- Amino acid substitutions in VP2 residues contacting sialic acid in low-neurovirulence BeAn virus dramatically reduce viral binding and spread of infection.Journal of virology · 2003Article
- Evolution of cell recognition by viruses: a source of biological novelty with medical implications.Advances in virus research · 2003Review
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanisms by which Theiler's murine encephalomyelitis virus (TMEV) binds and enters host cells and the molecules involved are not completely understood. In this study, we demonstrate that the high-neurovirulence TMEV GDVII virus uses the glycosaminoglycan heparan sulfate (HS) as an attachment factor that is required for efficient infection. Studies based on soluble HS-mediated inhibition of attachment and infection, removal of HS with specific enzymes, and blocking with anti-HS antibodies establish that HS mediates GDVII virus entry into mammalian cells. Data from defined proteoglycan-deficient Chinese hamster ovary mutant cells further support the role of HS in GDVII infection and indicate that the extent of sulfation is critical for infection. Neuraminidase treatment of proteoglycan-deficient cells restores permissiveness to GDVII virus, indicating that sialic acid hinders direct access of virus to the protein entry receptor. A model of the potential steps in GDVII virus entry into mammalian cells involving HS is proposed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.