ArticleJournal of virology2002
Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy.Frontiers in immunology · 2018Review
- Article
- SHP-1-dependent macrophage differentiation exacerbates virus-induced myositis.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Inhibitors of myelination: ECM changes, CSPGs and PTPs.Experimental neurology · 2014Article
- Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects.Journal of neuroimmunology · 2012Article
- Human metapneumovirus inhibits IFN-β signaling by downregulating Jak1 and Tyk2 cellular levels.PloS one · 2011Article
- Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1.Viral immunology · 2009Article
- Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1.Clinical immunology (Orlando, Fla.) · 2009Article
- Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype.Laboratory investigation; a journal of technical methods and pathology · 2009Article
- Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease.Journal of virology · 2009Article
- Significance of SHP-1 and SHP-2 expression in human papillomavirus infected Condyloma acuminatum and cervical cancer.Pathology oncology research : POR · 2008Article
- Promoter-specific induction of the phosphatase SHP-1 by viral infection and cytokines in CNS glia.Journal of neurochemistry · 2008Article
- SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.Laboratory investigation; a journal of technical methods and pathology · 2008Article
- Modulation of gene expression in a human cell line caused by poliovirus, vaccinia virus and interferon.Virology journal · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We previously characterized the expression and function of the protein tyrosine phosphatase SHP-1 in the glia of the central nervous system (CNS). In the present study, we describe the role of SHP-1 in virus infection of glia and virus-induced demyelination in the CNS. For in vivo studies, SHP-1-deficient mice and their normal littermates received an intracerebral inoculation of an attenuated strain of Theiler's murine encephalomyelitis virus (TMEV). At various times after infection, virus replication, TMEV antigen expression, and demyelination were monitored. It was found that the CNS of SHP-1-deficient mice uniquely displayed demyelination and contained substantially higher levels of virus than did that of normal littermate mice. Many infected astrocytes and oligodendrocytes were detected in both brains and spinal cords of SHP-1-deficient but not normal littermate mice, showing that the virus replicated and spread at a much higher rate in the glia of SHP-1-deficient animals. To ascertain whether the lack of SHP-1 in the glia was primarily responsible for these differences, glial samples from these mice were cultured in vitro and infected with TMEV. As in vivo, infected astrocytes and oligodendrocytes of SHP-1-deficient mice were much more numerous and produced more virus than did those of normal littermate mice. These findings indicate that SHP-1 is a critical factor in controlling virus replication in the CNS glia and virus-induced demyelination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.