ArticleJournal of general internal medicine2002
Clinical importance of HIV and depressive symptoms among veterans with HIV infection.
Article in Journal of general internal medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.
- Systematic review and meta-analysis on the effect of depression on ART adherence among women living with HIV.PloS one · 2024Pooled it
- Assessing the Effectiveness of Multilevel Intervention Sequences on "Tension" Among Men Living with HIV: A Randomized-Control Trial.International journal of behavioral medicine · 2025Trial
- Trial
- Modified Antiretroviral Treatment Access Study (MARTAS): A Randomized Controlled Trial of the Efficacy of a Linkage-to-Care Intervention Among HIV-Positive Patients in Ukraine.AIDS and behavior · 2020Trial
- Health-related quality of life in subjects with HCV/HIV coinfection: results from ACTG 5178 study.Journal of viral hepatitis · 2012Trial
- Trial
- Rationale, study design and sample characteristics of a randomized controlled trial of directly administered antiretroviral therapy for HIV-infected prisoners transitioning to the community - a potential conduit to improved HIV treatment outcomes.Contemporary clinical trials · 2012Trial
- Home-based, peer-led chronic illness self-management training: findings from a 1-year randomized controlled trial.Annals of family medicineTrial
- The effect of depression on antiretroviral drug non-adherence among women living with HIV in Gondar health facilities, northwest Ethiopia: a prospective cohort study.Frontiers in psychiatry · 2025Article
- Depression and HIV Care-seeking Behaviors in a Population-based Sample in North West Province, South Africa.AIDS and behavior · 2023Article
- Comprehensive Geriatric Assessment in Older Persons With HIV.Open forum infectious diseases · 2020Review
- Social and behavioural factors associated with risky sexual behaviours among university students in nine ASEAN countries: a multi-country cross-sectional study.SAHARA J : journal of Social Aspects of HIV/AIDS Research Alliance · 2018Article
- Long-term physical and mental health outcomes associated with traumatic brain injury severity in post-9/11 veterans: A retrospective cohort study.Brain injury · 2018Article
- Psychological Wellbeing in the Face of Adversity among American Indians: Preliminary Evidence of a New Population Health Paradox?Annals of public health and research · 2016Article
- Validation of a Measure of Family Resilience among Iraq and Afghanistan Veterans.Military behavioral health · 2016Article
- Validity of Center for Epidemiologic Studies Depression (CES-D) scale in a sample of Iraq and Afghanistan Veterans.SAGE open medicine · 2016Article
- Contraceptive non-use and associated factors among university students in 22 countries.African health sciences · 2015Article
- Nocturnal sleep problems among university students from 26 countries.Sleep & breathing = Schlaf & Atmung · 2015Article
- Observational
- Depression and social functioning among HIV-infected and uninfected persons in South Africa.AIDS care · 2015Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the clinical importance (association with illness severity and survival) of depressive and HIV symptoms among veterans with HIV infection.
designCross-sectional study; survival analysis.
settingInfectious Disease Clinics at 3 VA Medical Centers.
participantsHIV-infected patients (N = 881) and their health care providers from June 1999 through July 2000. MEASUREMENTS AND MAIN
resultsDepressive symptoms were assessed using the 10-item Centers for Epidemiologic Studies Depression Scale (CES-D). Patient baseline survey included an HIV Symptom Index measuring the frequency and bother of 20 common symptoms. Providers were surveyed on patients' illness severity, and survival data were obtained from VA death records. Of 881 patients, 46% had significant depressive symptoms (CES-D >/=10). Increasing depression symptom severity was associated with increasing HIV symptom frequency (P <.001) and bother (P <.001). Multiple regression results revealed that having moderate or severe depressive symptoms was not associated with provider-reported illness severity or survival. However, HIV symptoms were significantly associated with provider-reported illness severity (P <.01) and survival (P =.05), after adjusting for moderate and severe depressive symptoms, CD4 cell count/mm3, viral load, age, race, and antiretroviral use.
conclusionsDepression, while common in this sample, was not associated with illness severity or mortality after adjusting for HIV symptoms. HIV symptoms are associated with severity of illness and survival regardless of patients' severity of depressive symptoms. This suggests that equal medical consideration should be given to HIV symptoms presented by HIV-infected patients regardless of their depression status, rather than automatically attributing medical complaints to depression.
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