ArticleBiophysical journal2002
Supramolecular properties of the proline-rich gamma-Zein N-terminal domain.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 60 citations in OpenAlex.
- Thin-Plate Superstructures of the Immunogenic 33-mer Gliadin Peptide.Chembiochem : a European journal of chemical biology · 2022Article
- Increasing the Efficiency of the Accumulation of Recombinant Proteins in Plant Cells: The Role of Transport Signal Peptides.Plants (Basel, Switzerland) · 2022Review
- Chemical biology tools for probing transcytosis at the blood-brain barrier.Chemical science · 2019Article
- Towards Developing Bioresponsive, Self-Assembled Peptide Materials: Dynamic Morphology and Fractal Nature of Nanostructured Matrices.Materials (Basel, Switzerland) · 2018Article
- The Encapsulation of Hemagglutinin in Protein Bodies Achieves a Stronger Immune Response in Mice than the Soluble Antigen.Frontiers in plant science · 2016Article
- A Fusion between Domains of the Human Bone Morphogenetic Protein-2 and Maize 27 kD γ-Zein Accumulates to High Levels in the Endoplasmic Reticulum without Forming Protein Bodies in Transgenic Tobacco.Frontiers in plant science · 2016Article
- Comparison of membrane targeting strategies for the accumulation of the human immunodeficiency virus p24 protein in transgenic tobacco.International journal of molecular sciences · 2013Article
- Protein bodies in nature and biotechnology.Molecular biotechnology · 2013Article
- Expression of a new chimeric protein with a highly repeated sequence in tobacco cells.Plant cell reports · 2011Article
- Relevant elements of a maize gamma-zein domain involved in protein body biogenesis.The Journal of biological chemistry · 2010Article
- Higher accumulation of F1-V fusion recombinant protein in plants after induction of protein body formation.Plant molecular biology · 2010Article
- Induction of protein body formation in plant leaves by elastin-like polypeptide fusions.BMC biology · 2009Article
- Eukaryotic protein production in designed storage organelles.BMC biology · 2009Article
- Recent developments in peptide-based nucleic acid delivery.International journal of molecular sciences · 2008Article
- Zeolin. A new recombinant storage protein constructed using maize gamma-zein and bean phaseolin.Plant physiology · 2004Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Zeins are maize storages proteins that accumulate inside large vesicles called protein bodies. gamma-Zein lines the inner face of the protein body membrane, and its N-terminal proline-rich repetitive domain with the sequence (VHLPPP)(8) appears to be necessary for the accumulation of the protein within the organelle. Synthetic (VHLPPP)(8) adopts an amphipathic polyproline II conformation. In a preliminary recent work we used atomic force microscopy to study the surface organization of the octamer and transmission electron microscopy to visualize aggregates of the peptide from aqueous solution. We previously envisioned two self-assembly models (i.e., the geometric and the micellar) that take into account the observed features. In the present work we studied in detail the self-assembly of the peptide in solution and found that the peptide is able to form cylindrical micelles. Fibrils formed on graphite are generated by assembly of solution micelles. Based on the results of these studies, we focused exclusively on the micellar model. To our knowledge we have characterized for the first time supramolecular aggregates of polyproline structures other than collagen. The spontaneous arrangement of (VHLPPP)(8) suggests a role for the N-terminal domain of gamma-zein in the process of the whole protein deposition in protein bodies.
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