ArticleBiophysical journal2002
Exploration of molecular interactions in cholesterol superlattices: effect of multibody interactions.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 77 citations in OpenAlex.
- Imidazole-Based pH-Sensitive Convertible Liposomes for Anticancer Drug Delivery.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Review
- Parameterization of a coarse-grained model of cholesterol with point-dipole electrostatics.Journal of computer-aided molecular design · 2018Article
- Membrane effects of N-terminal fragment of apolipoprotein A-I: a fluorescent probe study.Journal of fluorescence · 2015Article
- Acceleration of Lateral Equilibration in Mixed Lipid Bilayers Using Replica Exchange with Solute Tempering.Journal of chemical theory and computation · 2014Article
- Formation of cholesterol bilayer domains precedes formation of cholesterol crystals in cholesterol/dimyristoylphosphatidylcholine membranes: EPR and DSC studies.The journal of physical chemistry. B · 2013Article
- Series of concentration-induced phase transitions in cholesterol/phosphatidylcholine mixtures.Biophysical journal · 2013Article
- Phase separation in lipid membranes.Cold Spring Harbor perspectives in biology · 2011Review
- Comparison of three ternary lipid bilayer mixtures: FRET and ESR reveal nanodomains.Biophysical journal · 2010Article
- Cholesterol-phospholipid interactions: new insights from surface x-ray scattering data.Physical review letters · 2010Article
- Effect of cholesterol on the structure of a phospholipid bilayer.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Model membrane thermodynamics and lateral distribution of cholesterol: from experimental data to Monte Carlo simulation.Methods in enzymology · 2009Article
- Phase diagrams and lipid domains in multicomponent lipid bilayer mixtures.Biochimica et biophysica acta · 2009Review
- Interfacial behavior of cholesterol, ergosterol, and lanosterol in mixtures with DPPC and DMPC.Biophysical journal · 2008Article
- Use of fluorescence to determine the effects of cholesterol on lipid behavior in sphingomyelin liposomes and erythrocyte membranes.Journal of lipid research · 2008Article
- Phase studies of model biomembranes: complex behavior of DSPC/DOPC/cholesterol.Biochimica et biophysica acta · 2007Article
- Visualization of membrane rafts using a perylene monoimide derivative and fluorescence lifetime imaging.Biophysical journal · 2007Article
- Assess the nature of cholesterol-lipid interactions through the chemical potential of cholesterol in phosphatidylcholine bilayers.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Phase boundaries and biological membranes.Annual review of biophysics and biomolecular structure · 2007Review
- Phase behavior of lipid mixtures.Nature chemical biology · 2006Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental evidences have indicated that cholesterol may adapt highly regular lateral distributions (i.e., superlattices) in a phospholipid bilayer. We investigated the formations of superlattices at cholesterol mole fraction of 0.154, 0.25, 0.40, and 0.5 using Monte Carlo simulation. We found that in general, conventional pairwise-additive interactions cannot produce superlattices. Instead, a multibody (nonpairwise) interaction is required. Cholesterol superlattice formation reveals that although the overall interaction between cholesterol and phospholipids is favorable, it contains two large opposing components: an interaction favoring cholesterol-phospholipid mixing and an unfavorable acyl chain multibody interaction that increases nonlinearly with the number of cholesterol contacts. The magnitudes of interactions are in the order of kT. The physical origins of these interactions can be explained by our umbrella model. They most likely come from the requirement for polar phospholipid headgroups to cover the nonpolar cholesterol to avoid the exposure of cholesterol to water and from the sharp decreasing of acyl chain conformation entropy due to cholesterol contact. This study together with our previous work demonstrate that the driving force of cholesterol-phospholipid mixing is a hydrophobic interaction, and multibody interactions dominate others over a wide range of cholesterol concentration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.