ArticleThe Journal of physiology2002
Characterization of four types of background potassium channels in rat cerebellar granule neurons.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55 citing papers in PubMed, 119 citations in OpenAlex.
- A Direct Interaction between Cyclodextrins and TASK Channels Decreases the Leak Current in Cerebellar Granule Neurons.Biology · 2022Article
- Activity of TREK-2-like Channels in the Pyramidal Neurons of Rat Medial Prefrontal Cortex Depends on Cytoplasmic Calcium.Biology · 2021Article
- Contribution of Neuronal and Glial Two-Pore-Domain Potassium Channels in Health and Neurological Disorders.Neural plasticity · 2021Review
- Tandem pore TWIK-related potassium channels and neuroprotection.Neural regeneration research · 2019Review
- Depression of neuronal excitability and epileptic activities by group II metabotropic glutamate receptors in the medial entorhinal cortex.Hippocampus · 2015Article
- Role of K₂p channels in stimulus-secretion coupling.Pflugers Archiv : European journal of physiology · 2015Review
- Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.Physiological reviews · 2015Review
- Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Unidirectional photoreceptor-to-Müller glia coupling and unique K+ channel expression in Caiman retina.PloS one · 2014Article
- Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells.The Journal of physiology · 2013Article
- TASK-1 channels in oligodendrocytes: a role in ischemia mediated disruption.Neurobiology of disease · 2013Article
- A new TASK for Dipeptidyl Peptidase-like Protein 6.PloS one · 2013Article
- Vasopressin facilitates GABAergic transmission in rat hippocampus via activation of V(1A) receptors.Neuropharmacology · 2012Article
- SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.Science signaling · 2012Article
- Modulation of K2P3.1 (TASK-1), K2P9.1 (TASK-3), and TASK-1/3 heteromer by reactive oxygen species.Pflugers Archiv : European journal of physiology · 2012Article
- Activation of TREK currents by the neuroprotective agent riluzole in mouse sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Biophysical properties of human medulloblastoma cells.The Journal of membrane biology · 2010Article
- Distinct modes of modulation of GABAergic transmission by Group I metabotropic glutamate receptors in rat entorhinal cortex.Hippocampus · 2010Article
- The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide.British journal of pharmacology · 2009Article
- The response of the tandem pore potassium channel TASK-3 (K(2P)9.1) to voltage: gating at the cytoplasmic mouth.The Journal of physiology · 2009Article
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4 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Cerebellar granule neurons express a standing outward (background) K+ current (I(K,SO)) that regulates the resting membrane potential and cell excitability. As several tandem-pore (2P) K+ channel mRNAs are highly expressed in cerebellar granule cells, we studied whether, and which, 2P K+ channels contribute to I(K,SO). I(K,SO) was highly sensitive to changes in extracellular pH and was partially inhibited by acetylcholine, as reported previously. In cell-attached patches from cultured cerebellar granule neurons, four types of K+ channels were found to be active when membrane potential was held at -50 mV or +50 mV in symmetrical 140 mM KCl. Based on single-channel conductances, gating kinetics and modulation by pharmacological agents and pH, three K+ channels could be considered as functional correlates of TASK-1, TASK-3 and TREK-2, which are members of the 2P K+ channel family. The fourth K+ channel (Type 4) has not been described previously and its molecular correlate is not yet known. Based on the measurement of channel current densities, the Type 2 (TASK-3) and the Type 4 K+ channels were determined to be the major sources of I(K,SO) in cultured cerebellar granule neurons. The Type 1 (TASK-1) and Type 3 (TREK-2) activities were relatively low throughout cell growth in culture (1-10 days). Similar to TASK-1 and TASK-3, the Type 4 K+ channel was highly sensitive to changes in extracellular pH, showing a 78 % inhibition by changing the extracellular pH from 7.3 to 6.3. The results of this study show that three 2P K+ channels and an additional pH-sensing K+ channel (Type 4) comprise the I(K,SO) in cultured cerebellar granule neurons. Our results also show that the high sensitivity of I(K,SO) to extracellular pH comes from the high sensitivity of Type 2 (TASK-3) and Type 4 K+ channels.
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