ArticleThe Journal of physiology2002
Physical mobilization of secretory vesicles facilitates neuropeptide release by nerve growth factor-differentiated PC12 cells.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Beyond the brain: early autonomic dysfunction in Alzheimer's disease.Acta neuropathologica communications · 2025Article
- The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis.The Journal of general physiology · 2018Review
- Podocyte Purinergic P2X4 Channels Are Mechanotransducers That Mediate Cytoskeletal Disorganization.Journal of the American Society of Nephrology : JASN · 2016Article
- Mycalolide B dissociates dynactin and abolishes retrograde axonal transport of dense-core vesicles.Molecular biology of the cell · 2015Article
- Astroglial excitability and gliotransmission: an appraisal of Ca2+ as a signalling route.ASN neuro · 2012Review
- Spatial regulation of exocytic site and vesicle mobilization by the actin cytoskeleton.PloS one · 2011Article
- Dynamics of peptidergic secretory granule transport are regulated by neuronal stimulation.BMC neuroscience · 2010Article
- Expression of the dominant-negative tail of myosin Va enhances exocytosis of large dense core vesicles in neurons.Cellular and molecular neurobiology · 2009Article
- The role of actin remodeling in the trafficking of intracellular vesicles, transporters, and channels: focusing on aquaporin-2.Pflugers Archiv : European journal of physiology · 2008Review
- Signaling for vesicle mobilization and synaptic plasticity.Molecular neurobiology · 2008Review
- Presynaptic ryanodine receptor-activated calmodulin kinase II increases vesicle mobility and potentiates neuropeptide release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Analysis of transient behavior in complex trajectories: application to secretory vesicle dynamics.Biophysical journal · 2006Article
- Motion matters: secretory granule motion adjacent to the plasma membrane and exocytosis.Molecular biology of the cell · 2006Article
- Mechanisms of transport and exocytosis of dense-core granules containing tissue plasminogen activator in developing hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- A deeper look into single-secretory vesicle dynamics.Biophysical journal · 2004Review
- Unexpected mobility variation among individual secretory vesicles produces an apparent refractory neuropeptide pool.Biophysical journal · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
It has been speculated that neurosecretion can be enhanced by increasing the motion, and hence, the availability of cytoplasmic secretory vesicles. However, facilitator-induced physical mobilization of secretory vesicles has not been observed directly in living cells, and recent experimental results call this hypothesis into question. Here, high resolution green fluorescent protein (GFP)-based measurements in nerve growth factor-differentiated PC12 cells are used to test whether altering dense core vesicle (DCV) motion affects neuropeptide release. Experiments with mycalolide B and jasplakinolide demonstrate that neuropeptidergic DCV motion at the ends of processes is proportional to F-actin. Furthermore, Ba2+ increases DCV mobility without detectably modifying F-actin. Finally, we show that altering DCV motion by changing F-actin or stimulating with Ba2+ proportionally changes sustained neuropeptide release. Therefore, increasing DCV mobility facilitates prolonged neuropeptide release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.