ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
The projections of early enteric neurons are influenced by the direction of neural crest cell migration.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 110 citations in OpenAlex.
- Time-resolved morphological and transcriptomic characterization of early enteric neuron subtype emergence in chick.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Combinatorial multiomic analysis from a pedigree of Sox10Dom Hirschsprung mice identifies multiple high confidence candidate modifiers of Enteric Nervous System development.PLoS computational biology · 2026Article
- Combinatorial multiomic analysis from a pedigree of Sox10bioRxiv : the preprint server for biology · 2025Article
- Mature enteric neurons have the capacity to reinnervate the intestine with glial cells as their guide.Neuron · 2024Article
- The transcriptional portraits of the neural crest at the individual cell level.Seminars in cell & developmental biology · 2023Review
- Neonatal development of intestinal neuroimmune interactions.Trends in neurosciences · 2022Review
- Development of the Gastrointestinal Tract in Newborns as a Challenge for an Appropriate Nutrition: A Narrative Review.Nutrients · 2022Review
- Automated computational analysis reveals structural changes in the enteric nervous system of nNOS deficient mice.Scientific reports · 2021Article
- Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury.The Journal of clinical investigation · 2021Review
- Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing.Nature neuroscience · 2021Article
- Review
- Mapping of Extrinsic Innervation of the Gastrointestinal Tract in the Mouse Embryo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Kif1bp loss in mice leads to defects in the peripheral and central nervous system and perinatal death.Scientific reports · 2017Article
- Exposure to GDNF Enhances the Ability of Enteric Neural Progenitors to Generate an Enteric Nervous System.Stem cell reports · 2017Article
- Enteric glia: the most alimentary of all glia.The Journal of physiology · 2017Review
- Arundic Acid Prevents Developmental Upregulation of S100B Expression and Inhibits Enteric Glial Development.Frontiers in cellular neuroscience · 2017Article
- Molecular fingerprinting delineates progenitor populations in the developing zebrafish enteric nervous system.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Bowel dysfunction following pullthrough surgery is associated with an overabundance of nitrergic neurons in Hirschsprung disease.Journal of pediatric surgery · 2016Article
- Neuronal Differentiation in Schwann Cell Lineage Underlies Postnatal Neurogenesis in the Enteric Nervous System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Building a second brain in the bowel.The Journal of clinical investigation · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The enteric nervous system arises from the neural crest. In embryonic mice, vagal neural crest cells enter the developing foregut at approximately embryonic day 9.5 (E9.5) and then migrate rostrocaudally to colonize the entire gastrointestinal tract by E14.5. This study showed that a subpopulation of vagal crest-derived cells, very close to the migratory wavefront, starts to differentiate into neurons early, as shown by the expression of neuron-specific proteins and the absence of Sox10. Many of the early differentiating neurons transiently exhibited tyrosine hydroxylase (TH) immunoreactivity. The TH cells were demonstrated to be the progenitors of nitric oxide synthase (NOS) neurons. Immunohistochemistry, lesions, and DiI tracing were used to examine the projections of developing enteric neurons. The axons of first neurons in the gut (the TH-NOS neurons) projected in the same direction (caudally), and traversed the same pathways through the mesenchyme, as the migrating, undifferentiated, vagal crest-derived cells. To examine if the direction of migration and direction of axon projection are linked, coculture experiments were set up in which vagal crest-derived cells migrated either rostrocaudally (as they do in vivo), or caudorostrally (which they do not normally do), to colonize explants of embryonic aneural hindgut. The direction in which neurons projected was correlated with the direction of cell migration, but migration direction appears to be not the only mechanism influencing axon projection. Peristaltic reflexes involve both orally (rostrally) projecting neurons and anally (caudally) projecting neurons. Because few rostrally projecting neurons could be detected before birth, the full circuitry for peristaltic reflexes appears to develop after birth.
Indexed as
Identifiers
12122062PMC6757928W1819730896What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.